1. GPCR/G Protein
    Anti-infection
  2. Prostaglandin Receptor
    SARS-CoV
  3. KW-8232 free base

KW-8232 free base 

Cat. No.: HY-100304 Purity: ≥95.0%
Handling Instructions

KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.

For research use only. We do not sell to patients.

KW-8232 free base Chemical Structure

KW-8232 free base Chemical Structure

CAS No. : 170365-25-0

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1 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis of PGE2[1].

IC50 & Target

Prostaglandin Receptor[1]

In Vitro

KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].
KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC50 ~1.2 μM )[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male Sprague-Dawley rats (5-week-old)[1].
Dosage: 1, 3, 10, and 30 mg/kg.
Administration: Orally once daily beginning 1 day prior to neurectomy for 28 days.
Result: Decreased urinary calcium excreation in the neurectomized rats only at 30 mg/kg.
Molecular Weight

609.16

Formula

C₃₆H₃₇ClN₄O₃

CAS No.
SMILES

O=C(C(N1CCN(C)C)=C(C(C2=CC=C(O)C=C2)C3=CC=C(O)C=C3)C4=C1C=CC=C4)N5CCN(C6=CC=CC=C6Cl)CC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥95.0%

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Keywords:

KW-8232KW8232KW 8232Prostaglandin ReceptorSARS-CoVSARS coronavirusInhibitorinhibitorinhibit

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KW-8232 free base
Cat. No.:
HY-100304
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