1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. KW-8232 free base

KW-8232 free base 

Cat. No.: HY-100304
Handling Instructions

KW-8232 free base is an anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.

For research use only. We do not sell to patients.

KW-8232 free base Chemical Structure

KW-8232 free base Chemical Structure

CAS No. : 170365-25-0

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1 mg USD 1690 Ask For Quote & Lead Time
5 mg USD 2705 Ask For Quote & Lead Time
10 mg USD 4328 Ask For Quote & Lead Time

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KW-8232 free base is an anti-osteoporotic agent, and can reduces the biosynthesis of PGE2.

IC50 & Target

Prostaglandin Receptor[1]

In Vitro

KW-8232 free base is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE2 in mouse osteoblastic cells[1].

In Vivo

KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production[1].

Molecular Weight









Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Animal Administration

After male Sprague-Dawley rats (5-week-old) are anesthetized with sodium pentobarbital (30 mg/kg, i.p.), a dorsolateral incision is made on the right hip through which the sciatic nerve is exposed, and a 0.5-cm section is excised. The contralateral leg is left intact. KW-8232 is dissolved in distilled water and administered orally at 1, 3, 10, and 30 mg/kg once daily beginning 1 day prior to neurectomy. On day 28, rats are exsanguinated under diethyl ether agter obtaining urine, and their femurs are removed. Bone mineral density (BMD) is determined by dual energy x-ray absorptiometry. Twenty-four hour urine samples are collected from the animals, which are fasted immediately after the final administration of KW-8232[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

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