1. Epigenetics
    Apoptosis
  2. MicroRNA
    Apoptosis
  3. MIR96-IN-1

MIR96-IN-1 

Cat. No.: HY-15843 Purity: ≥98.0%
Handling Instructions

MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively.

For research use only. We do not sell to patients.

MIR96-IN-1 Chemical Structure

MIR96-IN-1 Chemical Structure

CAS No. : 1311982-88-3

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 544 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 544 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 180 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 600 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

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Based on 1 publication(s) in Google Scholar

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Description

MIR96-IN-1 targets the Drosha site in the miR-96 (miRNA-96, microRNA-96) hairpin precursor, inhibiting its biogenesis, derepressing downstream targets, and triggering apoptosis in breast cancer cells. MIR96-IN-1 binds to RNAs with Kds of 1.3, 9.4, 3.4, 1.3 and 7.4 μM for RNA1, RNA2, RNA3, RNA4 and RNA5, respectively[1].

In Vitro

MIR96-IN-1 (Compound 1) selectively inhibits production of mature miR-96 and triggers apoptosis in breast cancer cells at micromolar concentrations[1].
MIR96-IN-1 (Compound 3) binds a UU loop in miR-96 and inhibits its biogenesis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

588.79

Formula

C₃₃H₄₈N₈O₂

CAS No.
SMILES

O=C(NCCCN=[N+]=[N-])CCCOC1=C(C(C)(C)C)C=C(C2=NC3=CC=C(N4CCN(C)CC4)C=C3N2)C=C1C(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (169.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6984 mL 8.4920 mL 16.9840 mL
5 mM 0.3397 mL 1.6984 mL 3.3968 mL
10 mM 0.1698 mL 0.8492 mL 1.6984 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.25 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.25 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MIR96-IN-1MicroRNAApoptosismiRNAInhibitorinhibitorinhibit

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Product Name:
MIR96-IN-1
Cat. No.:
HY-15843
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