1. Metabolic Enzyme/Protease
  2. Phosphatase

Microcystin-LR (Synonyms: Cyanoginosin-LR; MC-LR; Toxin T 17 (Microcystis aeruginosa))

Cat. No.: HY-P0072 Purity: >95.0%
Handling Instructions

Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively. Sequence: Ala-D-Ala-Leu-D-{Bas}-Arg-{Oaa}-D-{Ggu}.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Microcystin-LR Chemical Structure

Microcystin-LR Chemical Structure

CAS No. : 101043-37-2

Size Price Stock Quantity
0.5 mM * 100 uL in Ethanol USD 84 In-stock
Estimated Time of Arrival: December 31
0.5 mM * 200 uL in Ethanol USD 120 In-stock
Estimated Time of Arrival: December 31
1 mg   Get quote  
5 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively. Sequence: Ala-D-Ala-Leu-D-{Bas}-Arg-{Oaa}-D-{Ggu}.

IC50 & Target

IC50: 1.7 nM (PP1), 0.04 nM (PP2A)[1].

In Vitro

Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication[2]. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration[1].

Solvent & Solubility
In Vitro: 

Ethanol : 0.5 mg/mL (0.50 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0049 mL 5.0243 mL 10.0485 mL
5 mM 0.2010 mL 1.0049 mL 2.0097 mL
10 mM 0.1005 mL 0.5024 mL 1.0049 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

995.17

Formula

C₄₉H₇₄N₁₀O₁₂

CAS No.

101043-37-2

Storage
Pure form -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: >95.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Microcystin-LR
Cat. No.:
HY-P0072
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Microcystin-LR

Cat. No.: HY-P0072