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hache-hbace-1-in-4

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161512
    hAChE/hBACE-1-IN-4

    		Cholinesterase (ChE) Amyloid-β Neurological Disease
    hAChE/hBACE-1-IN-4 (compound AK-2) is a quinazoline derivative. hAChE/hBACE-1-IN-4 shows significant inhibitory activity against hAChE and hBACE-1 enzymes (hAChE, IC50=0.283 μM; hBACE-1, IC50=0.231 μM). hAChE/hBACE-1-IN-4 has the potential to inhibit Aβ aggregation. hAChE/hBACE-1-IN-4 has non-neurotoxicity , blood-brain barrier permeability and oral activity. hAChE/hBACE-1-IN-4 can be used in Alzheimer's disease research .
    <em>hAChE/hBACE</em>-1-IN-4

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