2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. NADPH Oxidase

NADPH Oxidase

NOX

NADPH Oxidase

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NADPH-oxidase (NOX) is a highly regulated dynamic complex comprising membrane and cytosolic proteins and is the major source of nonmitochondrial cellular reactive oxygen species (ROS). The ROS generated by NADPH oxidases have crucial roles in various physiological processes, including innate immunity, modulation of redox-dependent signalling cascades, and as cofactors in the production of hormones.

NOX enzymes are a family of transmembrane proteins comprising seven members (NOX1-NOX5 and DUOX1 and DUOX2), each with a specific tissue distribution and activation mechanism. They catalyze the reduction of molecular oxygen to superoxide anion, which in turn reacts quickly to generate other ROS, such as hydrogen peroxide. Although basic NOX activity is crucial for normal physiology, overshooting activity of NOX enzymes leads to disease. NADPH oxidases are increasingly recognized as interesting drug targets.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P5381
    gp91 ds-tat
    		Inhibitor
    gp91 ds-tat is a biological active peptide. (NADPH oxidase assembly peptide inhibitor)
    gp91 ds-tat
  • HY-12803
    Fulvene-5
    		Inhibitor
    Fulvene-5 is a potent NADPH oxidase 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (ROS) modifying agent and a potent radioprotector. Fulvene-5 has antitumor activity.
    Fulvene-5
  • HY-P5328
    Noxa A BH3
    Noxa A BH3 is a biological active peptide. (BH3 domain of Noxa protein)
    Noxa A BH3
  • HY-P5329
    r8-Gly-Noxa A BH3
    r8-Gly-Noxa A BH3 is a biological active peptide. (This cell permeable peptide is derived from the BH3 domain (a death domain) of Noxa A, amino acid residues 17 to 36. Eight D-Arginine residues and a Glycine linker residue are added to the amino terminal of the peptide.)
    r8-Gly-Noxa A BH3
  • HY-P5330
    Noxa B BH3
    Noxa B BH3 is a biological active peptide. (BH3 domain of Noxa protein)
    Noxa B BH3
  • HY-B0203B
    (Rac)-Nebivolol
    		Inhibitor
    (Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity.
    (Rac)-Nebivolol
  • HY-121097
    Diapocynin
    		Inhibitor
    Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities.
    Diapocynin
  • HY-153978
    GLX481369
    		Inhibitor
    GLX481369 is a redox active substance. GLX481369 is a Nox4 inhibitor. GLX481369 has antioxidant effects.
    GLX481369
  • HY-153977
    GLX481304
    		Inhibitor ≥99.0%
    GLX481304 is a specific inhibitor of Nox-2 and -4, with IC50s of 1.25 μM. GLX481304 suppresses ROS production in isolated mouse cardiomyocytes and improves cardiomyocyte contractility. GLX481304 can be used for research of ischemic injury to the heart.
    GLX481304
  • HY-156425
    NOX2-IN-2
    		Inhibitor
    NOX2-IN-2 (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 inhibits ROS production derived from NOX2 in cells.
    NOX2-IN-2
Cat. No. Product Name / Synonyms Application Reactivity