Prolyl Endopeptidase (PREP)

prolyl oligopeptidase; POP

Prolyl endopeptidase (PREP), also known as prolyl oligopeptidase (POP), a member of the serine protease family, which can specifically hydrolyze the peptide bond of the carboxylterminus of the proline residue in the polypeptide chain, has high activity in the liver. Accumulated evidence suggests that PREP participates in physiological and pathological processes, including maturation and degradation of peptides, inflammation, oxidative stress, autophagy, cell proliferation and cancer.

Prolyl Endopeptidase (PREP) Inhibitors (21)

Prolyl Endopeptidase (PREP) Related Products (23):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-134454A

Z-Pro-prolinal	Inhibitor
Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC₅₀ of 0.4 nM for porcine PREP.

HY-125432

Poststatin	Inhibitor
Poststatin is a pecific prolyl endopeptidase (PEP) inhibitor. Poststatin inhibits bradykinin-degrading enzymes in rat urine.

HY-107758

Y-29794 oxalate	Inhibitor
Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM).

Name
Email *

	Sorry, but the email address you supplied was invalid.