1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Prolyl Endopeptidase (PREP)
  4. Prolyl Endopeptidase (PREP) Inhibitor

Prolyl Endopeptidase (PREP) Inhibitor

Prolyl Endopeptidase (PREP) Inhibitors (21):

Cat. No. Product Name Effect Purity
  • HY-N0109
    Salidroside
    Inhibitor 99.79%
    Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
  • HY-W404002
    BR102910
    Inhibitor 99.80%
    BR102910 is a selective fibroblast activation protein (FAP) inhibitor with the IC50 of 2 nM. BR102910 also inhibits prolyl oligopeptidase (PREP) with the IC50 of 49.00 μM. BR102910 can be used for the researchof type 2
  • HY-15114
    S 17092
    Inhibitor 98.42%
    S 17092 (S 17092-1) is a potent cerebral prolyl-endopeptidase (PEP) inhibitor with an IC50 of 1.2 nM. S 17092 can be used for the research of memory impairment and cognitive disorders associated with cerebral aging.
  • HY-113951
    Prolyl Endopeptidase Inhibitor 1
    Inhibitor 98.34%
    Prolyl Endopeptidase Inhibitor 1 (Boc-Pro-prolinal) is a potent prolyl endopeptidase (PEP; PE) inhibitor, with a Ki value of 15 nM. Prolyl Endopeptidase Inhibitor 1 has anti-amnesic effect.
  • HY-N2481
    Oroxylin A-7-O-glucuronide
    Inhibitor 99.83%
    Oroxylin A-7-O-glucuronide (Oroxyloside; Oroxylin A-7-O-β-D-glucuronide) is a flavonoid glucuronide isolated from the dried root of Scutellaria baicalensis, with prolyl oligopeptidase (POP) inhibitory activity.
  • HY-N0109R
    Salidroside (Standard)
    Inhibitor
    Salidroside (Standard) is the analytical standard of Salidroside. This product is intended for research and analytical applications. Salidroside (Rhodioloside) is a prolyl endopeptidase inhibitor. Salidroside alleviates cachexia symptoms in mouse models of cancer cachexia via activating mTOR signalling. Salidroside protects dopaminergic neurons by enhancing PINK1/Parkin-mediated mitophagy.
  • HY-P4308
    Z-Pro-Pro-aldehyde-dimethyl acetal
    Inhibitor
    Z-Pro-Pro-aldehyde-dimethyl acetal is a potent inhibitor of prolyl endopeptidase (PREP), a cytoplasmic serine endoprotease (IC50= 12 nM). Z-Pro-Pro-aldehyde-dimethyl acetal plays an important role in cognitive dysfunction in aging and neurodegenerative diseases including Alzheimer's disease.
  • HY-100475
    KYP-2047
    Inhibitor 99.68%
    KYP-2047 is a potent and BBB-penetrating prolyl-oligopeptidase (POP) inhibitor, with an Ki value of 0.023 nM. KYP-2047 reduces glioblastoma proliferation through angiogenesis and apoptosis modulation.
  • HY-17455
    Pramiracetam
    Inhibitor ≥98.0%
    Pramiracetam (CI-879 free base) is a PREP (prolyl endopeptidase) inhibitor. Pramiracetam improves cognitive impairment caused by traumatic brain injury. Pramiracetam can be used in the study of neurodegenerative diseases.
  • HY-N2454
    β-Elemonic acid
    Inhibitor 99.90%
    β-Elemonic acid is a triterpene isolated from Boswellia carterii. β-Elemonic acid induces cell apoptosis, reactive oxygen species (ROS) and COX-2 expression and inhibits prolyl endopeptidase. β-Elemonic acid exhibits anticancer and anti-inflammatory effects.
  • HY-143475
    POP-IN-2
    Inhibitor
    POP-IN-2 (Compound 7k) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a Ki of 6 nM. POP-IN-2 can be used for studying neurodegenerative diseases and cancer.
  • HY-148332
    Z-Thioprolyl-Thiazolidine
    Inhibitor
    Z-Thioprolyl-Thiazolidine is a potent and specific prolyl endopeptidase inhibitor with an Ki value of 0.36 nM for bovine brain prolyl endopeptidase
  • HY-139648
    PREP inhibitor-1
    Inhibitor
    PREP inhibitor-1 is a highly potent prolyl oligopeptidase (PREP) inhibitor (IC50 < 1 nM).
  • HY-N6902
    Linderene acetate
    Inhibitor 99.31%
    Linderene acetate, isolated from the root of Lindera strychnifolia, is a prolyl endopeptidase inhibitor.
  • HY-148331
    Z-Thioprolyl-Thioproline
    Inhibitor
    Z-Thioprolyl-Thioproline is a bovine brain prolyl endopeptidase (PEP) inhibitor (IC50=16 µM; Ki=37 µM). Z-Thioprolyl-Thioproline is used in the study of neurological disorders such as memory disorders and cognitive disorders.
  • HY-143474
    Y-29794
    Inhibitor
    Y-29794 (Compound 2) is a potent, covalent prolyl oligopeptidase (POP) inhibitor with a Ki of 0.95 nM. Y-29794 can be used for studying neurodegenerative diseases and cancer.
  • HY-15112
    JTP-4819
    Inhibitor
    JTP-4819 is a potent and specific inhibitor of prolyl endopeptidase (PREP) with IC50s of 0.83 nM (in rat brain supernatant) and 5.43 nM (in Flavobacterium meningosepticum). JTP-4819 has blood-brain penetration, also improves the retention time of amnesia rats induced by Scopolamine (HY-N2096).
  • HY-134454A
    Z-Pro-prolinal
    Inhibitor
    Z-Pro-prolinal (N-Benzyloxycarbonyl-L-prolyl-L-prolinal) is a specific, orally active prolyl endopeptidase (PREP) inhibitor with an IC50 of 0.4 nM for porcine PREP.
  • HY-125432
    Poststatin
    Inhibitor
    Poststatin is a pecific prolyl endopeptidase (PEP) inhibitor. Poststatin inhibits bradykinin-degrading enzymes in rat urine.
  • HY-107758
    Y-29794 oxalate
    Inhibitor
    Y-29794 oxalate is a selective, orally active and blood-brain barrier permeable non-peptide prolyl endopeptidase inhibitor. Y-29794 oxalate blocks the IRS1-AKT-mTORC1 pathway and inhibits tumor growth. Y-29794 oxalate is also effective in inhibiting the progression of Aβ-like deposition in the hippocampus of aging-accelerated mice (SAM).