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Z-321 

Cat. No.: HY-19123
Handling Instructions

Z-321 is a prolylendopeptidase (PEP) inhibitor.

For research use only. We do not sell to patients.

Z-321 Chemical Structure

Z-321 Chemical Structure

CAS No. : 130849-58-0

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Z-321 is a prolylendopeptidase (PEP) inhibitor.

IC50 & Target

PEP[1]

In Vivo

Z-321 is a prolylendopeptidase (PEP) inhibitor. In the 100 or 200 mg/kg Z-321-treated groups, mean lordosis quotient (LQ) decreases after administration. However, there is no statistical difference among the values before and after. In contrast, the mean LQ in the 300 mg/kg Z-321-treated females is lower than that before injection (P<0.005). Furthermore, when compare to that in the vehicle-treated control group, mean LQ is also significantly lower (p<0.05). The incidence of soliciting behavior decreases after treatment with 300 mg/kg Z-321, when compare to that before treatment, but there is no statistical difference. The present study also demonstrates that 300 mg/kg Z-321 is effective in inhibiting lordosis behavior without disturbance of locomotor activity[1].

References
Animal Administration
[1]

Femal wistar rats (200 to 250 g) are used and housed under conditions of controlled temperature (23 to 26°C) and photoperiod (14: 10 h, light:dark). Fifty four rats are ovariectomized under ether anesthesia. Two weeks after ovariectomy, sexual behavioral tests are carried out before and after a treatment with Z-321 (100, 200 or 300 mg/kg). Another group of rats, 7 females are given 1 mL/kg of 10% gum arabic as control group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

344.47

Formula

C₁₉H₂₄N₂O₂S

CAS No.

130849-58-0

SMILES

O=C([[email protected]]1N(C(CC2CC3=C(C=CC=C3)C2)=O)CSC1)N4CCCC4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Z-321
Cat. No.:
HY-19123
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Z-321

Cat. No.: HY-19123