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Cat. No.: HY-19123
Handling Instructions

Z-321 is a prolylendopeptidase (PEP) inhibitor.

For research use only. We do not sell to patients.

Z-321 Chemical Structure

Z-321 Chemical Structure

CAS No. : 130849-58-0

Size Price Stock
1 mg USD 563 Get quote
5 mg USD 901 Get quote
10 mg USD 1442 Get quote

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Z-321 is a prolylendopeptidase (PEP) inhibitor.

IC50 & Target


In Vivo

Z-321 is a prolylendopeptidase (PEP) inhibitor. In the 100 or 200 mg/kg Z-321-treated groups, mean lordosis quotient (LQ) decreases after administration. However, there is no statistical difference among the values before and after. In contrast, the mean LQ in the 300 mg/kg Z-321-treated females is lower than that before injection (P<0.005). Furthermore, when compare to that in the vehicle-treated control group, mean LQ is also significantly lower (p<0.05). The incidence of soliciting behavior decreases after treatment with 300 mg/kg Z-321, when compare to that before treatment, but there is no statistical difference. The present study also demonstrates that 300 mg/kg Z-321 is effective in inhibiting lordosis behavior without disturbance of locomotor activity[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9030 mL 14.5151 mL 29.0301 mL
5 mM 0.5806 mL 2.9030 mL 5.8060 mL
10 mM 0.2903 mL 1.4515 mL 2.9030 mL
*Please refer to the solubility information to select the appropriate solvent.
Animal Administration

Femal wistar rats (200 to 250 g) are used and housed under conditions of controlled temperature (23 to 26°C) and photoperiod (14: 10 h, light:dark). Fifty four rats are ovariectomized under ether anesthesia. Two weeks after ovariectomy, sexual behavioral tests are carried out before and after a treatment with Z-321 (100, 200 or 300 mg/kg). Another group of rats, 7 females are given 1 mL/kg of 10% gum arabic as control group[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight







O=C([[email protected]]1N(C(CC2CC3=C(C=CC=C3)C2)=O)CSC1)N4CCCC4


Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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Cat. No.: HY-19123