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Pramiracetam 

Cat. No.: HY-17455 Purity: >98.0%
Handling Instructions

Pramiracetam is a nootropic drug derived from piracetam, and is more potent. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries.

For research use only. We do not sell to patients.

Pramiracetam Chemical Structure

Pramiracetam Chemical Structure

CAS No. : 68497-62-1

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10 mM * 1 mL in DMSO USD 169 In-stock
Estimated Time of Arrival: December 31
50 mg USD 154 In-stock
Estimated Time of Arrival: December 31
200 mg USD 426 In-stock
Estimated Time of Arrival: December 31
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Description

Pramiracetam is a nootropic drug derived from piracetam, and is more potent. Pramiracetam reportedly improved cognitive deficits associated with traumatic brain injuries. IC50 Value: Target: in vitro: Pramiracetam sulfate did not exhibit any affinity in vitro for dopaminergic , GABAergic, serotoninergic, adrenergic, muscarinic, adenosine (IC50 > 10 uM), and benzodiazepine receptors (IC50 > 1 uM) binding sites [1]. in vivo: In a double-blind, randomized design, two groups of six subjects each received alternating placebo and single 400, 800, 1,200, and 1,600 mg oral doses of pramiracetam after an overnight fast. Mean (+/- SD) peak plasma concentrations of the four dose groups (2.71 +/- 0.54, 5.40 +/- 1.34, 6.13 +/- 0.71, 8.98 +/- 0.71 micrograms/mL) were attained between two to three hours following drug administration [2]. Two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which nine arms were baited with food [3].

Molecular Weight

269.38

Formula

C₁₄H₂₇N₃O₂

CAS No.

68497-62-1

SMILES

O=C(NCCN(C(C)C)C(C)C)CN1C(CCC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (371.22 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7122 mL 18.5611 mL 37.1223 mL
5 mM 0.7424 mL 3.7122 mL 7.4245 mL
10 mM 0.3712 mL 1.8561 mL 3.7122 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.28 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.28 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

PramiracetamOthersInhibitorinhibitorinhibit

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Pramiracetam
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