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A3334 

Cat. No.: HY-131448 Purity: 99.86%
Handling Instructions

A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH.

For research use only. We do not sell to patients.

A3334 Chemical Structure

A3334 Chemical Structure

CAS No. : 854171-31-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 385 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

A3051 is a potent and orally active inhibtor of CXXC5-DVL extracted from patent WO2020079569, has an IC50 of 63.06 nM. A3334 can be used for the research of high fat diet (HFD)-induced and methionine-choline deficient diet (MCD)-induced phenotypes such as obesity, diabetes, and NASH[1].

IC50 & Target

IC50: 63.06 nM (CXXC5-DVL)[1]

In Vitro

A3334 (1-10 μM) efficiently inhibits the adipogenic differentiation of 3T3-L1 preadipocytes via the Wnt/β-eatenin signaling pathway[1].
A3334 (1-10 μM; 24 h) enhances the TOPFlash reporter activity in HEK293-TOP cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

A3334 (25 mg/kg; p.o. once daily for 16 weeks) has anti-obesity effects in the HFD mice, and has no effect on mice fed with normal diet[1].
A3334 (25 mg/kg; p.o. once daily for 5 days) significantly reduces fasting glucose and the levels of glucose tolerance (GTT) and insulin tolerance (ITT) in serum in mice[1].
A3334 (25 mg/kg; p.o. once daily for 3 weeks) significantly abolishes hepatosteatosis and the increased levels of alanine transaminase (ALT) and aspartatetransaminase (AST) in mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6N mice (6-week-old) are fed on the high fat die (HFD) for 16 weeks[1]
Dosage: 25 mg/kg
Administration: P.o. daily for 16 weeks
Result: Not observed the HFD-induced body weight gain and abdominal obesity.
Reduced the level of triglyceride and total cholesterol and increased the level of HDL-cholesterol.
Suppressed the increase in adipocyte cell sizes and enhancement of inflammation.
Molecular Weight

307.30

Formula

C₁₇H₁₃N₃O₃

CAS No.

854171-31-6

SMILES

O=C1NC2=C(C=C(OC)C=C2)/C1=C3NC4=C(C=CC=C4)C/3=N/O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (813.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2541 mL 16.2707 mL 32.5415 mL
5 mM 0.6508 mL 3.2541 mL 6.5083 mL
10 mM 0.3254 mL 1.6271 mL 3.2541 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.77 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

A3334A 3334A-3334OthersCXXC5DVLhighfatdietHFDmethioninecholinedeficientMCDobesitydiabetesand NASHInhibitorinhibitorinhibit

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Product Name:
A3334
Cat. No.:
HY-131448
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