Antibacterial agent 166 

Antibacterial agent 166 (Compound 19q), a derivative of Nitisinone (HY-B0607), is a selective and orally active Fusobacterium nucleatum inhibitor with a MIC₅₀ of 1 μg/mL. Antibacterial agent 166 effectively attenuates the migratory ability of MC-38 cells induced by Fusobacterium nucleatum. Antibacterial agent 166 is a promising anti-F. nucleatum lead compound and can be used for colorectal cancer (CRC) research^[1].

Antibacterial agent 166 (Compound 19q) (1-4 μg/mL, 0-72 h) inhibits the growth and biofilm formation of Fusobacterium nucleatum in a dose dependent manner^[1].
Antibacterial agent 166 (1-4 μg/mL, 4-48 h) inhibits the growth of Fusobacterium nucleatum by downregulating the expression of NTR^[1].
Antibacterial agent 166 (1-4 μg/mL, 48 h) downregulates the expression of the tnaA gene in the late-log-phase in a dose-dependent manner^[1].
Antibacterial agent 166 (2-4 μg/mL, 48 h) possesses stronger migratory inhibition potency against MC-38 under the stimulation of Fusobacterium nucleatum^[1].
Antibacterial agent 166 exhibits the most potent inhibitory activity against MC-38 cells, with an IC₅₀ of 11 μM^[1].
Antibacterial agent 166, exhibits moderate to weak antiproliferative activity two human normal cell lines with an IC₅₀ of 16 μM, possess low cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antibacterial agent 166 (Compound 19q) (1500 mg/kg, single dose) has little toxic side effects on the organs^[1].
Antibacterial agent 166 (20 mg/kg, p.o, single dose) can inhibit Fusobacterium nucleatum locally in the intestinal tract and has lower systemic toxicity^[1].
Antibacterial agent 166 (1 mg/kg, Intravenous injection) half-life is approximately 0.068 h, the peak concentration C_max and plasma clearance (CL) were 85 ng/mL and 36054 mL/h/mg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

281.65

C₁₁H₈ClN₃O₄

ClC1=CN=C(CNC(C2=CC=C([N+]([O-])=O)O2)=O)C=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pan Z, et al. Discovery of New Fusobacterium nucleatum Inhibitors to Attenuate Migratory Capability of Colon Cancer Cells by the Drug Repositioning Strategy. Journal of Medicinal Chemistry. 2023 Nov 20.