39S ribosomal protein L41, mitochondrial

Definition:

Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.

References:

[1]. Alexey Amunts, et al. Ribosome. The structure of the human mitochondrial ribosome. Science. 2015 Apr 3;348(6230):95-98. [Content Brief]

[2]. Alan Brown, et al. Structure of the large ribosomal subunit from human mitochondria. Science. 2014 Nov 7;346(6210):718-722. [Content Brief]

[3]. Alan Brown, et al. Structures of the human mitochondrial ribosome in native states of assembly. Nat Struct Mol Biol. 2017 Oct;24(10):866-869. [Content Brief]

[4]. Young A Yoo, et al. Mitochondrial ribosomal protein L41 suppresses cell growth in association with p53 and p27Kip1. Mol Cell Biol. 2005 Aug;25(15):6603-16. [Content Brief]

[5]. Mi Jin Kim, et al. Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1). Biochem Biophys Res Commun. 2005 Dec 16;338(2):1179-84. [Content Brief]

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