2. Academic Validation
  3. Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1)

Mitochondrial ribosomal protein L41 mediates serum starvation-induced cell-cycle arrest through an increase of p21(WAF1/CIP1)

  • Biochem Biophys Res Commun. 2005 Dec 16;338(2):1179-84. doi: 10.1016/j.bbrc.2005.10.064.
Mi Jin Kim 1,  Young A Yoo,  Hyung Jung Kim,  Seongman Kang,  Yong Geon Kim,  Jun Suk Kim,  Young Do Yoo
Affiliations

Affiliation

  • 1 Graduate School of Medicine, Korea University College of Medicine, Korea University, Seoul 136-705, Republic of Korea.
PMID: 16256947 DOI: 10.1016/j.bbrc.2005.10.064
Abstract

Ribosomal proteins not only act as components of the translation apparatus but also regulate cell proliferation and Apoptosis. A previous study reported that MRPL41 plays an important role in p53-dependent Apoptosis. It also showed that MRPL41 arrests the cell cycle by stabilizing p27(Kip1) in the absence of p53. This study found that MRPL41 mediates the p21(WAF1/CIP1)-mediated G1 arrest in response to serum starvation. The cells were released from serum starvation-induced G1 arrest via the siRNA-mediated blocking of MRPL41 expression. Overall, these results suggest that MRPL41 arrests the cell cycle by increasing the p21(WAF1/CIP1) and p27(Kip1) levels under the growth inhibitory conditions.

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