Alpha-

Definition:

Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.

References:

[1]. R Niemelä, et al. Complementary acceptor and site specificities of Fuc-TIV and Fuc-TVII allow effective biosynthesis of sialyl-TriLex and related polylactosamines present on glycoprotein counterreceptors of selectins. J Biol Chem. 1998 Feb 13;273(7):4021-6. [Content Brief]

[2]. Masahiko Miyashiro, et al. Development of a sensitive separation and quantification method for sialyl Lewis X and Lewis X involving anion-exchange chromatography: biochemical characterization of alpha1-3 fucosyltransferase-VII. J Biochem. 2004 Nov;136(5):723-31. [Content Brief]

[3]. N Kimura, et al. Reconstitution of functional L-selectin ligands on a cultured human endothelial cell line by cotransfection of alpha1-->3 fucosyltransferase VII and newly cloned GlcNAcbeta:6-sulfotransferase cDNA. Proc Natl Acad Sci U S A. 1999 Apr 13;96(8):4530-5. [Content Brief]

[4]. K Handa, et al. The alpha 1-->3 fucosylation at the penultimate GlcNAc catalyzed by fucosyltransferase VII is blocked by internally fucosylated residue in sialosyl long-chain poly-LacNAc: enzymatic basis for expression of physiological E-selectin epitope. Biochem Biophys Res Commun. 1998 Feb 4;243(1):199-204. [Content Brief]

[5]. Maëlle Prorok-Hamon, et al. N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding. Biochem J. 2005 Nov 1;391(Pt 3):491-502. [Content Brief]

[6]. S E Goelz, et al. ELFT: a gene that directs the expression of an ELAM-1 ligand. Cell. 1990 Dec 21;63(6):1349-56. [Content Brief]

[7]. Hideyuki Ihara, et al. Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8. Glycobiology. 2007 May;17(5):455-66. [Content Brief]

[8]. R N Knibbs, et al. The fucosyltransferase FucT-VII regulates E-selectin ligand synthesis in human T cells. J Cell Biol. 1996 May;133(4):911-20. [Content Brief]

[9]. P Bengtson, et al. Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene. J Biol Chem. 2001 Aug 24;276(34):31575-82. [Content Brief]

[10]. Yuanyuan Zhang, et al. Overexpression of fucosyltransferase VII (FUT7) promotes embryo adhesion and implantation. Fertil Steril. 2009 Mar;91(3):908-14. [Content Brief]

[11]. Qiu-yan Wang, et al. Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway. FEBS J. 2007 Jan;274(2):526-38. [Content Brief]

[12]. M R Stroud, et al. Fucosylation of complex glycosphingolipids by recombinant fucosyltransferase-VII. Biochem Biophys Res Commun. 1997 Sep 8;238(1):165-8. [Content Brief]

[13]. Shuai Liu, et al. FUT7 antisense sequence inhibits the expression of FUT7/sLeX and adhesion between embryonic and uterine cells. IUBMB Life. 2008 Jul;60(7):461-6. [Content Brief]

[14]. Bobby G Ng, et al. Biallelic Mutations in FUT8 Cause a Congenital Disorder of Glycosylation with Defective Fucosylation. Am J Hum Genet. 2018 Jan 4;102(1):188-195. [Content Brief]

[15]. Nandini Mondal, et al. Distinct human α(1,3)-fucosyltransferases drive Lewis-X/sialyl Lewis-X assembly in human cells. J Biol Chem. 2018 May 11;293(19):7300-7314. [Content Brief]

[16]. R N Knibbs, et al. Alpha(1,3)-fucosyltransferase VII-dependent synthesis of P- and E-selectin ligands on cultured T lymphoblasts. J Immunol. 1998 Dec 1;161(11):6305-15. [Content Brief]

[17]. Jun Zhang, et al. The α1,3-fucosyltransferase FUT7 regulates IL-1β-induced monocyte-endothelial adhesion via fucosylation of endomucin. Life Sci. 2018 Jan 1;192:231-237. [Content Brief]

[18]. K Shinoda, et al. Enzymatic characterization of human alpha1,3-fucosyltransferase Fuc-TVII synthesized in a B cell lymphoma cell line. J Biol Chem. 1997 Dec 19;272(51):31992-7. [Content Brief]

[19]. C J Britten, et al. Acceptor specificity of the human leukocyte alpha3 fucosyltransferase: role of FucT-VII in the generation of selectin ligands. Glycobiology. 1998 Apr;8(4):321-7. [Content Brief]

[20]. K Shinoda, et al. Panosialins, inhibitors of an alpha1,3-fucosyltransferase Fuc-TVII, suppress the expression of selectin ligands on U937 cells. Glycoconj J. 1998 Nov;15(11):1079-83. [Content Brief]

[21]. P Malý, et al. The alpha(1,3)fucosyltransferase Fuc-TVII controls leukocyte trafficking through an essential role in L-, E-, and P-selectin ligand biosynthesis. Cell. 1996 Aug 23;86(4):643-53. [Content Brief]

[22]. Rosella Mollicone, et al. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). J Biol Chem. 2009 Feb 13;284(7):4723-38. [Content Brief]

[23]. S Natsuka, et al. Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. J Biol Chem. 1994 Jun 17;269(24):16789-94. [Content Brief]

[24]. S Yanagidani, et al. Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells. J Biochem. 1997 Mar;121(3):626-32. [Content Brief]

[25]. J B Lowe, et al. Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. J Biol Chem. 1991 Sep 15;266(26):17467-77. [Content Brief]

[26]. F Nakayama, et al. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. J Biol Chem. 2001 May 11;276(19):16100-6. [Content Brief]

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