BRCA1-associated ATM activator 1

Definition

Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress. Plays a role in regulating mitochondrial function and cell proliferation. Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors.

References:

[1]. Jason A Aglipay, et al. ATM activation by ionizing radiation requires BRCA1-associated BAAT1. J Biol Chem. 2006 Apr 7;281(14):9710-8. [Content Brief]

[2]. Eui Young So, et al. BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction. BMC Cancer. 2014 Jul 29;14:548. [Content Brief]

[3]. Eui Young So, et al. Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit. Exp Ther Med. 2011 May;2(3):443-447. [Content Brief]

[4]. Eui Young So, et al. The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR. J Cancer Biol Res. 2013 Jul-Aug;1(1):1001. [Content Brief]

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