2. Academic Validation
  3. The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR

The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR

  • J Cancer Biol Res. 2013 Jul-Aug;1(1):1001.
Eui Young So 1,  Toru Ouchi 1
Affiliations

Affiliation

  • 1 Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, NY, USA.
PMID: 25657994
Abstract

BRCA1-associated ATM activator-1 (BRAT1) was identified by our group as a DNA damage response (DDR) protein, which can bind with many DDR proteins and regulates their functions after DNA damage. However, previous study has also implicated BRAT1 as a regulator of cell growth and Apoptosis. In this study, targeted gene deletion showed that BRAT1 is critical in stability and serum-induced expression of mTOR and downstream protein. Conditional deletion of BRAT1 of mouse embryonic fibroblasts suppressed serum-induced cell cycling progress. Our results suggest that BRAT1 is essential factor for PIKK signaling cascades.

Keywords

BRCA1; Cell cycle; Cell signaling; Human cervical carcinoma.

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