Centrosomal protein of 68 kDa

Definition

Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase. Contributes to CROCC/rootletin filament formation.

References:

[1]. Susanne Graser, et al. Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion. J Cell Sci. 2007 Dec 15;120(Pt 24):4321-31. [Content Brief]

[2]. Yuqing Xia, et al. CCDC102B functions in centrosome linker assembly and centrosome cohesion. J Cell Sci. 2018 Dec 3;131(23):jcs222901. [Content Brief]

[3]. Guoliang Fang, et al. Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion. J Cell Sci. 2014 Apr 15;127(Pt 8):1631-9. [Content Brief]

[4]. Julia K Pagan, et al. Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing. Nat Cell Biol. 2015 Jan;17(1):31-43. [Content Brief]

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