D-glucuronyl C5-epimerase

Definition:

Converts D-glucuronic acid residues adjacent to N-sulfate sugar residues to L-iduronic acid residues, both in maturing heparan sulfate (HS) and heparin chains. This is important for further modifications that determine the specificity of interactions between these glycosaminoglycans and proteins.

References:

[1]. Juzheng Sheng, et al. Uncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesis. J Biol Chem. 2012 Jun 15;287(25):20996-1002. [Content Brief]

[2]. Kai Li, et al. Using engineered 2-O-sulfotransferase to determine the activity of heparan sulfate C5-epimerase and its mutants. J Biol Chem. 2010 Apr 9;285(15):11106-13. [Content Brief]

[3]. Claire Debarnot, et al. Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase. Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):6760-6765. [Content Brief]

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