DNA helicase B

Definition:

5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection. Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB. As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation. Acts independently of TP53BP1. Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress.

References:

[1]. Ján Tkáč, et al. HELB Is a Feedback Inhibitor of DNA End Resection. Mol Cell. 2016 Feb 4;61(3):405-418. [Content Brief]

[2]. Poonam Taneja, et al. A dominant-negative mutant of human DNA helicase B blocks the onset of chromosomal DNA replication. J Biol Chem. 2002 Oct 25;277(43):40853-61. [Content Brief]

[3]. Gulfem Dilek Guler, et al. Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress. J Biol Chem. 2012 Feb 24;287(9):6469-81. [Content Brief]

[4]. Hanjian Liu, et al. Human DNA helicase B functions in cellular homologous recombination and stimulates Rad51-mediated 5'-3' heteroduplex extension in vitro. PLoS One. 2015 Jan 24;10(1):e0116852. [Content Brief]

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