FERM domain-containing protein 5

Definition:

May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation.

References:

[1]. Tao Wang, et al. FERM-containing protein FRMD5 is a p120-catenin interacting protein that regulates tumor progression. FEBS Lett. 2012 Sep 21;586(19):3044-50. [Content Brief]

[2]. Jinxia Hu, et al. FERM domain-containing protein FRMD5 regulates cell motility via binding to integrin β5 subunit and ROCK1. FEBS Lett. 2014 Nov 28;588(23):4348-56. [Content Brief]

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