FUN14 domain-containing protein 2

Definition:

Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways. May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes.

References:

[1]. Li-Li Gao, et al. HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the SREBP1c/FASN Pathway. J Cell Biochem. 2015 Oct;116(10):2375-84. [Content Brief]

[2]. Qi Ma, et al. Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway. Cell Death Differ. 2019 Jan;26(2):321-331. [Content Brief]

[3]. Xueliang Yang, et al. HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter. BMB Rep. 2018 Jan;51(1):33-38. [Content Brief]

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