2. Academic Validation
  3. HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter

HCBP6 upregulates human SREBP1c expression by binding to C/EBPβ-binding site in the SREBP1c promoter

  • BMB Rep. 2018 Jan;51(1):33-38. doi: 10.5483/bmbrep.2018.51.1.184.
Xueliang Yang 1,  Ming Han 2,  Shunai Liu 3,  Xiaoxue Yuan 3,  Xiaojing Liu 1,  Shenghu Feng 2,  Li Zhou 2,  Yaru Li 3,  Hongping Lu 3,  Jun Cheng 4,  Shumei Lin 1
Affiliations

Affiliations

  • 1 Department of Infectious Diseases, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China.
  • 2 Peking University Ditan Teaching Hospital, Beijing 100015; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015, China.
  • 3 Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015; Insitiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
  • 4 Peking University Ditan Teaching Hospital, Beijing 100015; Beijing Key Laboratory of Emerging Infectious Diseases, Beijing 100015; Insitiute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
PMID: 29187281 DOI: 10.5483/bmbrep.2018.51.1.184
Abstract

Sterol regulatory element-binding protein-1c (SREBP1c) plays an important role in triglyceride (TG) homeostasis. Although our previous study showed that hepatitis C virus core-binding protein 6 (HCBP6) regulates SREBP1c expression to maintain intracellular TG homeostasis, the mechanism underlying this regulation is unclear. In the present study, we found that HCBP6 increased intracellular TG levels by upregulating SREBP1c expression. HCBP6 increased SREBP1c transcription by directly binding to the SREBP1c promoter (at the -139- to +359-bp region). Moreover, we observed that HCBP6 interacted with C/EBPβ-binding site in the SREBP1c promoter both in vitro and in vivo. These results indicate that HCBP6 upregulates human SREBP1c expression by binding to the C/EBPβ-binding site in the SREBP1c promoter. [BMB Reports 2018; 51(1): 33-38].

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