Leprosy

Definition:

Leprosy, also called Hansen's disease, is a chronic infection caused by Mycobacterium leprae (M. leprae) and the more recently discovered Mycobacterium lepromatosis (M. lepromatosis). It primarily affects peripheral nerves, skin and mucosa particularly the upper respiratory tract.

References:

[1]. Alexandre Alcaïs, et al. Stepwise replication identifies a low-producing lymphotoxin-alpha allele as a major risk factor for early-onset leprosy. Nat Genet. 2007 Apr;39(4):517-22. [Content Brief]

[2]. Annemieke Geluk, et al. HLA and leprosy in the pre and postgenomic eras. Hum Immunol. 2006 Jun;67(6):439-45. [Content Brief]

[3]. Christopher M Johnson, et al. Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy. J Immunol. 2007 Jun 15;178(12):7520-4. [Content Brief]

[4]. Dheeraj Malhotra, et al. TLR2 Arg677Trp polymorphism in leprosy: revisited. Hum Genet. 2005 Apr;116(5):413-5. [Content Brief]

[5]. Laura C Rodrigues, et al. Leprosy now: epidemiology, progress, challenges, and research gaps. Lancet Infect Dis. 2011 Jun;11(6):464-70. [Content Brief]

[6]. Marcelo T Mira, et al. Susceptibility to leprosy is associated with PARK2 and PACRG. Nature. 2004 Feb 12;427(6975):636-40. [Content Brief]

[7]. Thomas Ploemacher, et al. Reservoirs and transmission routes of leprosy; A systematic review. PLoS Negl Trop Dis. 2020 Apr 27;14(4):e0008276. [Content Brief]

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