2. Academic Validation
  3. TLR2 Arg677Trp polymorphism in leprosy: revisited

TLR2 Arg677Trp polymorphism in leprosy: revisited

  • Hum Genet. 2005 Apr;116(5):413-5. doi: 10.1007/s00439-004-1249-9.
Dheeraj Malhotra 1,  Vineet Relhan,  B S N Reddy,  Ramesh Bamezai
Affiliations

Affiliation

  • 1 National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
PMID: 15726416 DOI: 10.1007/s00439-004-1249-9
Abstract

We investigated the Toll-like Receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogate TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls. The case-control comparison also involved investigation of possible variation(s) in the promoter region of the TLR2 gene. Genotyping results after direct PCR sequencing showed that the TLR2 Arg677Trp polymorphism associated with lepromatous leprosy in the Korean population is not a true polymorphism of the TLR2 gene and has resulted from the variation present in the 93% homologous duplicated region of TLR2 exon 3 present approximately 23 kb upstream.

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