Little elongation complex subunit 1

Definition:

Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically acts as a scaffold protein that promotes the LEC complex formation and recruitment and RNA polymerase II occupancy at snRNA genes in subnuclear bodies.

References:

[1]. Edwin R Smith, et al. The little elongation complex regulates small nuclear RNA transcription. Mol Cell. 2011 Dec 23;44(6):954-65. [Content Brief]

[2]. Deqing Hu, et al. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Mol Cell. 2013 Aug 22;51(4):493-505. [Content Brief]

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