Neurotensin receptor type 1

Definition:

G-protein coupled receptor for the tridecapeptide neurotensin (NTS). Signaling is effected via G proteins that activate a phosphatidylinositol-calcium second messenger system. Signaling leads to the activation of downstream MAP kinases and protects cells against apoptosis.

References:

[1]. N Vita, et al. Cloning and expression of a complementary DNA encoding a high affinity human neurotensin receptor. FEBS Lett. 1993 Feb 8;317(1-2):139-42. [Content Brief]

[2]. Grégory Da Costa, et al. Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor. J Biomol Struct Dyn. 2013 Dec;31(12):1381-92. [Content Brief]

[3]. Yasser Heakal, et al. Neurotensin receptor-1 inducible palmitoylation is required for efficient receptor-mediated mitogenic-signaling within structured membrane microdomains. Cancer Biol Ther. 2011 Sep 1;12(5):427-35. [Content Brief]

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