Pyruvate dehydrogenase kinase 3 (PDK3)

Definition:

Pyruvate dehydrogenase kinase 3 (PDK3) is a multifunctional enzyme that plays a central role in the cancer metabolic switch by blocking pyruvate catabolism in the TCA cycle.

References:

[1]. Mohammad T, et al. Identification of high-affinity inhibitors of pyruvate dehydrogenase kinase-3: towards therapeutic management of cancer. J Biomol Struct Dyn. 2021 Feb;39(2):586-594. [Content Brief]

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