RNA polymerase II elongation factor ELL

Definition:

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription. ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation.

References:

[1]. Jung S Byun, et al. ELL facilitates RNA polymerase II pause site entry and release. Nat Commun. 2012 Jan 17;3:633. [Content Brief]

[2]. A Shilatifard, et al. An RNA polymerase II elongation factor encoded by the human ELL gene. Science. 1996 Mar 29;271(5257):1873-6. [Content Brief]

[3]. Edwin R Smith, et al. The little elongation complex regulates small nuclear RNA transcription. Mol Cell. 2011 Dec 23;44(6):954-65. [Content Brief]

[4]. Deqing Hu, et al. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Mol Cell. 2013 Aug 22;51(4):493-505. [Content Brief]

[5]. Stephanie E Kong, et al. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10094-8. [Content Brief]

[6]. Chengqi Lin, et al. AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Mol Cell. 2010 Feb 12;37(3):429-37. [Content Brief]

[7]. Nanhai He, et al. HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription. Mol Cell. 2010 May 14;38(3):428-38. [Content Brief]

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