The kinin-kallikrein system (KKS)

Definition:

The kinin-kallikrein system (KKS) is an endogenous multiprotein cascade, the activation of which leads to triggering of the intrinsic coagulation pathway and enzymatic hydrolysis of kininogens with the consequent release of bradykinin-related peptides.

References:

[1]. Elena Kashuba, et al. The kinin-kallikrein system: physiological roles, pathophysiology and its relationship to cancer biomarkers. Biomarkers. 2013 Jun;18(4):279-96. [Content Brief]

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