Tropomyosin receptor kinase (TRK)

Definition:

Tropomyosin receptor kinase (TRK) supports neuronal growth, survival, and differentiation during development, adult life, and aging. TRK downregulation is a prominent hallmark of various neurological disorders including Alzheimer's disease (AD). Abnormally expressed or overexpressed full-length or oncogenic fusion TRK proteins were shown to drive tumorigenesis in a variety of neurogenic and non-neurogenic human cancers.

References:

[1]. Schirrmacher R, et al. Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging. Pharmaceuticals (Basel). 2019 Jan 3;12(1):7. [Content Brief]

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