Zinc finger CCCH domain-containing protein 8

Definition:

Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene (By similarity). Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.

References:

[1]. Eun Sook Hwang, et al. Regulation of thymocyte homeostasis by Fliz1. Immunology. 2002 Aug;106(4):464-9. [Content Brief]

[2]. Deqing Hu, et al. The little elongation complex functions at initiation and elongation phases of snRNA gene transcription. Mol Cell. 2013 Aug 22;51(4):493-505. [Content Brief]

[3]. Eun Sook Hwang, et al. Transcriptional regulation of GATA-3 by an intronic regulatory region and fetal liver zinc finger protein 1. J Immunol. 2002 Jul 1;169(1):248-53. [Content Brief]

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