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  3. CAM741

CAM741 is a selective VCAM-1 translocation inhibitor. CAM741 selectively inhibits VCAM-1 expression by inhibiting its co-translational translocation within the lumen of the endoplasmic reticulum (ER). CAM741 can be used as a molecular tool and can also be used in the research of chronic inflammation and cancer.

For research use only. We do not sell to patients.

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CAM741 Chemical Structure

CAM741 Chemical Structure

CAS No. : 177586-74-2

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CAM741 Related Antibodies

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Description

CAM741 is a selective VCAM-1 translocation inhibitor. CAM741 selectively inhibits VCAM-1 expression by inhibiting its co-translational translocation within the lumen of the endoplasmic reticulum (ER). CAM741 can be used as a molecular tool and can also be used in the research of chronic inflammation and cancer[1][2].

In Vitro

CAM741 (5, 10, 50, 100 nM; 24 h) dose-dependently inhibits VCAM1 glycoprotein expression in transiently transfected HEK-293 cells[1].
CAM741 (10, 33, 100, 333 nM; 24 h) dose-dependently inhibits cotranslational translocation of VCAM1[1]. CAM741 inhibits VCAM1 translocation at a post-targeting step and enhances interaction of the VCAM1 nascent chains with Sec61β.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CAM741 Related Antibodies

Western Blot Analysis[1]

Cell Line: HEK-293 cells
Concentration: 5, 10, 50, 100 nM
Incubation Time: 24 h
Result: Inhibited VCAM1 glycoprotein expression in a dose-dependent manner.
Molecular Weight

1038.36

Formula

C56H91N7O11
CAS No.
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAM741177586-74-2CAM 741CAM-741Otherscancerchronic inflammationco-translational translocationERSec61 βInhibitorinhibitorinhibit

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