1. PROTAC Autophagy
  2. Ligands for E3 Ligase Autophagy
  3. Thalidomide-piperazine-pyrimidine-piperazine-C-boc

Thalidomide-piperazine-pyrimidine-piperazine-C-boc 

Cat. No.: HY-161201
Handling Instructions

Thalidomide-piperazine-pyrimidine-piperazine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperazine-pyrimidine-piperazine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

For research use only. We do not sell to patients.

Thalidomide-piperazine-pyrimidine-piperazine-C-boc Chemical Structure

Thalidomide-piperazine-pyrimidine-piperazine-C-boc Chemical Structure

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Description

Thalidomide-piperazine-pyrimidine-piperazine-C-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Thalidomide-piperazine-pyrimidine-piperazine-C-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

Cereblon (CRBN)[1]

Molecular Weight

618.68

Formula

C31H38N8O6

SMILES

O=C1NC(CCC1N2C(C3=C(C=CC(N4CCN(CC4)C5=NC=NC(N6CCN(CC6)CC(OC(C)(C)C)=O)=C5)=C3)C2=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Thalidomide-piperazine-pyrimidine-piperazine-C-boc Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Thalidomide-piperazine-pyrimidine-piperazine-C-boc
Cat. No.:
HY-161201
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