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ELOVL6-IN-1 

Cat. No.: HY-138768
Handling Instructions

ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA.

For research use only. We do not sell to patients.

ELOVL6-IN-1 Chemical Structure

ELOVL6-IN-1 Chemical Structure

CAS No. : 1185736-98-4

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 382 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 382 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 580 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2500 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].

IC50 & Target

IC50: 0.35 μM (ELOVL6), Ki: 994 nM (ELOVL6)[1]

In Vitro

ELOVL6-IN-1 has sufficiently lipophilic having the potential to penetrate the intracellular space in a passive diffusion manner[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1].
ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1].
ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice
Dosage: 10 mg/kg
Administration: P.o.
Result: Displayed appreciable plasma and liver exposure.
Animal Model: C57BL/6J mice
Dosage: 10 and 30 mg/kg
Administration: P.o.
Result: Reduced the elongation index of the liver lipids.
Animal Model: C57BL/6J mice
Dosage: 100 mg/kg
Administration: P.o.
Result: Reduced the elongation index of the total fatty acids of the liver.
Molecular Weight

495.49

Formula

C₂₇H₂₄F₃N₃O₃

CAS No.
SMILES

O=C1N(C2=CC=CC=C2)C3=C(C(C(C)(C)CC3)=O)C1(C4=C(C)NN(C5=CC=CC=C5)C4=O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (100.91 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0182 mL 10.0910 mL 20.1820 mL
5 mM 0.4036 mL 2.0182 mL 4.0364 mL
10 mM 0.2018 mL 1.0091 mL 2.0182 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ELOVL6-IN-1Otherspotentorallyselectivenoncompetitivemalonyl-CoApalmitoyl-CoAInhibitorinhibitorinhibit

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Product Name:
ELOVL6-IN-1
Cat. No.:
HY-138768
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