ELOVL6-IN-3
Based on 1 Customer Validation
ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA.
For research use only. We do not sell to patients.
- Purity: 99.19%
- CAS No.: 712346-06-0
- Formula: C27H24F3N3O3
- Molecular Weight:495.49
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
IC50: 0.35 μM (ELOVL6), Ki: 994 nM (ELOVL6)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| COS-7 | IC50 |
>10 nM
Compound: 1
|
Inhibition of human ELOVL3 expressed in african green monkey COS7 cells assessed as stearoyl-CoA elongation
Inhibition of human ELOVL3 expressed in african green monkey COS7 cells assessed as stearoyl-CoA elongation
|
[PMID: 19388647] |
| COS-7 | IC50 |
290 nM
Compound: 1
|
Inhibition of human ELOVL6 expressed in african green monkey COS7 cells assessed as palmitoyl-CoA elongation
Inhibition of human ELOVL6 expressed in african green monkey COS7 cells assessed as palmitoyl-CoA elongation
|
[PMID: 19388647] |
ELOVL6-IN-1 has sufficiently lipophilic having the potential to penetrate the intracellular space in a passive diffusion manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1].
ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 712346-06-0
-
Appearance Solid
-
Molecular Weight 495.49
-
Formula C27H24F3N3O3
-
Color White to off-white
-
SMILES
O=C1C(C2(C(F)(F)F)C(N(C3=C2C(CC(C)(C3)C)=O)C4=CC=CC=C4)=O)=C(C)NN1C5=CC=CC=C5
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (100.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (279 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
References
[1]. Shimamura K, et al. 5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool. J Pharmacol Exp Ther. 2009;330(1):249-256. [Content Brief]
[2]. Takahashi T, Nagase T, Sasaki T, et al. Synthesis and evaluation of a novel indoledione class of long chain fatty acid elongase 6 (ELOVL6) inhibitors. J Med Chem. 2009;52(10):3142-3145. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0182 mL | 10.0910 mL | 20.1820 mL | 50.4551 mL |
| 5 mM | 0.4036 mL | 2.0182 mL | 4.0364 mL | 10.0910 mL | |
| 10 mM | 0.2018 mL | 1.0091 mL | 2.0182 mL | 5.0455 mL | |
| 15 mM | 0.1345 mL | 0.6727 mL | 1.3455 mL | 3.3637 mL | |
| 20 mM | 0.1009 mL | 0.5046 mL | 1.0091 mL | 2.5228 mL | |
| 25 mM | 0.0807 mL | 0.4036 mL | 0.8073 mL | 2.0182 mL | |
| 30 mM | 0.0673 mL | 0.3364 mL | 0.6727 mL | 1.6818 mL | |
| 40 mM | 0.0505 mL | 0.2523 mL | 0.5046 mL | 1.2614 mL | |
| 50 mM | 0.0404 mL | 0.2018 mL | 0.4036 mL | 1.0091 mL | |
| 60 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8409 mL | |
| 80 mM | 0.0252 mL | 0.1261 mL | 0.2523 mL | 0.6307 mL | |
| 100 mM | 0.0202 mL | 0.1009 mL | 0.2018 mL | 0.5046 mL |
ELOVL6-IN-3 Related Classifications
HY-139451 Related Classifications
Powered by Bioz