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  4. ELOVL6-IN-3

ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA.

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ELOVL6-IN-3 Chemical Structure

ELOVL6-IN-3 Chemical Structure

CAS No. : 712346-06-0

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Based on 1 publication(s) in Google Scholar

ELOVL6-IN-3 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1].

IC50 & Target

IC50: 0.35 μM (ELOVL6), Ki: 994 nM (ELOVL6)[1]
In Vitro

ELOVL6-IN-1 has sufficiently lipophilic having the potential to penetrate the intracellular space in a passive diffusion manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELOVL6-IN-3 Related Antibodies
In Vivo

ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1].
? ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1].
? ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

495.49

Formula

C27H24F3N3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C(C2(C(F)(F)F)C(N(C3=C2C(CC(C)(C3)C)=O)C4=CC=CC=C4)=O)=C(C)NN1C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (100.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0182 mL 10.0910 mL 20.1820 mL
5 mM 0.4036 mL 2.0182 mL 4.0364 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0182 mL 10.0910 mL 20.1820 mL 50.4551 mL
5 mM 0.4036 mL 2.0182 mL 4.0364 mL 10.0910 mL
10 mM 0.2018 mL 1.0091 mL 2.0182 mL 5.0455 mL
15 mM 0.1345 mL 0.6727 mL 1.3455 mL 3.3637 mL
20 mM 0.1009 mL 0.5046 mL 1.0091 mL 2.5228 mL
25 mM 0.0807 mL 0.4036 mL 0.8073 mL 2.0182 mL
30 mM 0.0673 mL 0.3364 mL 0.6727 mL 1.6818 mL
40 mM 0.0505 mL 0.2523 mL 0.5046 mL 1.2614 mL
50 mM 0.0404 mL 0.2018 mL 0.4036 mL 1.0091 mL
60 mM 0.0336 mL 0.1682 mL 0.3364 mL 0.8409 mL
80 mM 0.0252 mL 0.1261 mL 0.2523 mL 0.6307 mL
100 mM 0.0202 mL 0.1009 mL 0.2018 mL 0.5046 mL
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ELOVL6-IN-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ELOVL6-IN-3712346-06-0OthersInhibitorinhibitorinhibit

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