1. Protein Tyrosine Kinase/RTK
  2. Anaplastic lymphoma kinase (ALK)
  3. Envonalkib citrate

Envonalkib citrate  (Synonyms: TQ-B3139 citrate; CT-71 citrate)

Cat. No.: HY-145566A
Handling Instructions

Envonalkib citrate is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib citrate can be used for the research of non-small cell lung cancer.

For research use only. We do not sell to patients.

Envonalkib citrate Chemical Structure

Envonalkib citrate Chemical Structure

CAS No. : 1867204-56-5

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Description

Envonalkib citrate is a potent and orally active inhibitor of ALK, with IC50s of 1.96 nM, 35.1 nM, and 61.3 nM for WT and mutated L1196M and G1269S-ALK. Envonalkib citrate can be used for the research of non-small cell lung cancer[1].

IC50 & Target

IC50: 1.96 nM (WT-ALK), 35.1 nM (mutated L1196M-ALK), 61.3 nM (mutated G1269S-ALK)[1]

In Vivo

Envonalkib citrate (formula I) (12.5-25 mg/kg; p.o. once daily for 14 days) inhibits the growth of human non-small cell lung cancer NCI-H2228 nude mice xenografts[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

698.52

Formula

C30H34Cl2FN5O9

CAS No.
SMILES

OC(CC(C(O)=O)(O)CC(O)=O)=O.COC1=CC(N2[C@H](CNCC2)C)=NC=C1C3=CN=C(N)C(O[C@@H](C4=C(C(F)=CC=C4Cl)Cl)C)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Envonalkib citrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Envonalkib citrate
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HY-145566A
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