Felvizumab (Synonyms: SB 209763; RSHZ19)

Cat. No.: HY-P99615: FAQs
Data Sheet

Molarity Calculator

Felvizumab (SB 209763) is a humanized IgG1κ monoclonal antibody directed to distinct neutralizing epitopes on the F glycoprotein of RSV.

For research use only. We do not sell to patients.

Felvizumab Chemical Structure

CAS No. : 167747-20-8

Size		Stock
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Felvizumab (SB 209763) is a humanized IgG1κ monoclonal antibody directed to distinct neutralizing epitopes on the F glycoprotein of RSV^[1]^[2].

IC₅₀ & Target

EC50: 0.49 μg/mL (RSV Type A in microneutralization assay), 0.95 μg/mL (RSV Type A in fusion inhibition assay)^[2]

In Vitro

Felvizumab (RSHZ19) (2 h or 4 h) inhibits RSV Type A with an EC₅₀ of 0.49 ± 0.37 μg/mL in microneutralization assay and with an EC₅₀ of 0.95 ± 0.13 μg/mL in fusion inhibition assay^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Felvizumab (RSHZ19) (0.625-5.0 mg/kg; intramuscular injection; once) is effective against A and B subtypes of RSV in the cotton rat model of RSV infection^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Cotton rats, RSV infection model^[2]
Dosage:	0.625, 1.25, 2.5, and 5.0 mg/kg
Administration:	Intramuscular injection, 1 day before infection
Result:	Significantly reduced lung RSV titer.

CAS No.

167747-20-8

SMILES

[Felvizumab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Fenton C, et al. Palivizumab: a review of its use as prophylaxis for serious respiratory syncytial virus infection. Paediatr Drugs. 2004;6(3):177-97. [Content Brief]

[2]. Johnson S, et al. A direct comparison of the activities of two humanized respiratory syncytial virus monoclonal antibodies: MEDI-493 and RSHZl9. J Infect Dis. 1999 Jul;180(1):35-40. [Content Brief]

Felvizumab Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Felvizumab167747-20-8SB 209763 RSHZ19SB209763SB-209763RSHZ19RSHZ 19RSHZ-19RSVRespiratory syncytial virusF glycoproteinCotton ratsmicroneutralization assayfusion inhibition assayInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks