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  4. Gastric Inhibitory Peptide, porcine

Gastric Inhibitory Peptide, porcine  (Synonyms: GIP (1-42), porcine)

製品番号: HY-P3579 純度: 99.12%
COA 取扱説明書 Technical Support

Gastric Inhibitory Peptide (GIP (1-42)), porcine is a porcine glucose-dependent insulinotropic polypeptide and inhibitor of pentagastrin-stimulated gastric acid secretion. Gastric Inhibitory Peptide, porcine stimulates endogenous somatostatin release. Gastric Inhibitory Peptide, porcine acts in a dose- and time-dependent manner in conscious, chronic gastric fistula-equipped rats.

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Gastric Inhibitory Peptide, porcine

Gastric Inhibitory Peptide, porcine 構造式

CAS 番号 : 11063-17-5

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1 mg $95 在庫あり
5 mg $290 在庫あり
10 mg $470 在庫あり
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Gastric Inhibitory Peptide, porcine 関連抗体

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製品説明

Gastric Inhibitory Peptide (GIP (1-42)), porcine is a porcine glucose-dependent insulinotropic polypeptide and inhibitor of pentagastrin-stimulated gastric acid secretion. Gastric Inhibitory Peptide, porcine stimulates endogenous somatostatin release. Gastric Inhibitory Peptide, porcine acts in a dose- and time-dependent manner in conscious, chronic gastric fistula-equipped rats[1].

体内実験

Porcine GIP-(1-42) (10 nmol/kg/h; i.v.; continuous infusion until end of experiment) exerts potent, dose-dependent inhibition of Pentagastrin (HY-A0261)-stimulated gastric acid secretion in conscious rats, with an IC50 of 0.96 nmol/kg/h and 109.3% inhibition at a dose of 10 nmol/kg/h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD rats (adult male, 300-400 g, chronic gastric fistula model)[1]
Dosage: 10 nmol/kg/h
Administration: i.v.; continuous infusion until end of experiment
Result: Inhibited pentagastrin-stimulated gastric acid secretion in a dose- and time-dependent manner.
Achieved an IC50 of 0.96 nmol /kg/h.
Reduced pentagastrin-stimulated gastric acid output to 33.8 μmol/30 min, corresponding to 109.3% inhibition relative to pentagastrin-only controls.
分子量

4975.55

分子式

C225H342N60O66S
CAS 番号
Appearance

Solid

Color

White to light yellow

Sequence Shortening

YAEGTFISDYSIAMDKIRQQDFVNWLLAQKGKKSDWKHNITQ
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

polypeptide, sealed storage, away from moisture and light, under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (polypeptide, sealed storage, away from moisture and light, under nitrogen)
溶剤 & 溶解度
体外: 

H2O : ≥ 33.33 mg/mL (6.70 mM)

DMSO : 5 mg/mL (1.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2010 mL 1.0049 mL 2.0098 mL
5 mM 0.0402 mL 0.2010 mL 0.4020 mL
10 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション

純度: 99.12%

COA (252 KB) RP-HPLC (255 KB) MS (73 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 5 mM 0.0402 mL 0.2010 mL 0.4020 mL 1.0049 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Gastric Inhibitory Peptide, porcine Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Gastric Inhibitory Peptide, porcine11063-17-5GIP (1-42), porcineInsulin ReceptorCHO-K1 cellsporcine glucose-dependent insulinotropic polypeptideGastric Inhibitory Peptidesomatostatinpentagastrin-stimulated gastric acid secretionconsciouschronic gastric fistula-equipped ratsInhibitorinhibitorinhibit

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製品名:
Gastric Inhibitory Peptide, porcine
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