PAPOLA - poly(A) polymerase alpha Gene

Also Known as PAP; PAP-alpha

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10914

About PAPOLA

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,502,376-96,567,116 (from NCBI)

This gene has 26 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 27.7), thyroid (RPKM 22.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PAPOLA Products (10)

mRNA Protein Name
NM_001252006.1 NP_001238935.1 poly(A) polymerase alpha isoform 2
NM_001252007.1 NP_001238936.1 poly(A) polymerase alpha isoform 3
NM_001293627.1 NP_001280556.1 poly(A) polymerase alpha isoform 4
NM_001293628.2 NP_001280557.1 poly(A) polymerase alpha isoform 5
NM_001293632.3 NP_001280561.1 poly(A) polymerase alpha isoform 5
NM_001363662.3 NP_001350591.1 poly(A) polymerase alpha isoform 6
NM_001363664.3 NP_001350593.1 poly(A) polymerase alpha isoform 7
NM_001363665.3 NP_001350594.1 poly(A) polymerase alpha isoform 8
NM_001363666.3 NP_001350595.1 poly(A) polymerase alpha isoform 9
NM_032632.5 NP_116021.2 poly(A) polymerase alpha isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables poly(A) RNA polymerase activity IDA
IDA: Inferred from direct assay
7590244 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7590244 GOA
Biological Process GO Annotation Evidence References Source
involved in co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway IDA
IDA: Inferred from direct assay
19224921 GOA
involved in mRNA 3'-end processing IDA
IDA: Inferred from direct assay
7590244 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAPOLA Protein Structure

PAP_central

PAP_central: Poly(A) polymerase central domain (17 - 364)

NTP_transf_2

NTP_transf_2: Nucleotidyltransferase domain (94 - 173)

PAP_RNA-bind

PAP_RNA-bind: Poly(A) polymerase predicted RNA binding domain (366 - 507)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
Protein Preferred Names Protein Names

poly(A) polymerase alpha

  • polynucleotide adenylyltransferase alpha

Related Diseases

Diseases Alias
46,Xx Sex Reversal 3

  • SRXX3

  • Chromosome Xq26 Duplication Syndrome

  • 46,Xx Sex Reversal, Sox3-Related

  • 46xx Sex Reversal 3

  • 46,Xx Male Sex Reversal Sox3-Related
Combat Disorder

  • Combat Disorders

  • Combat Neurosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10026 PAPOLA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PAPOLA VGNC VGNC:80891
Canis familiaris PAPOLA VGNC VGNC:50551
Mus musculus PAPOLA MGD MGI:109301
Rattus norvegicus PAPOLA RGD RGD:1308673
Macaca mulatta PAPOLA VGNC VGNC:84415
Others PAPOLA NCBI