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  3. PAPOLA - poly(A) polymerase alpha Gene

PAPOLA - poly(A) polymerase alpha Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PAP; PAP-alpha

Gene ID: 10914 | Gene type: protein coding

About PAPOLA

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,502,376-96,567,116 (from NCBI)

This gene has 26 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 27.7), thyroid (RPKM 22.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the poly(A) polymerase family. It is required for the addition of adenosine residues for the creation of the 3'-poly(A) tail of mRNAs. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PAPOLA Products(10)

mRNA Protein Name
NM_001252006.1 NP_001238935.1 poly(A) polymerase alpha isoform 2
NM_001252007.1 NP_001238936.1 poly(A) polymerase alpha isoform 3
NM_001293627.1 NP_001280556.1 poly(A) polymerase alpha isoform 4
NM_001293628.2 NP_001280557.1 poly(A) polymerase alpha isoform 5
NM_001293632.3 NP_001280561.1 poly(A) polymerase alpha isoform 5
NM_001363662.3 NP_001350591.1 poly(A) polymerase alpha isoform 6
NM_001363664.3 NP_001350593.1 poly(A) polymerase alpha isoform 7
NM_001363665.3 NP_001350594.1 poly(A) polymerase alpha isoform 8
NM_001363666.3 NP_001350595.1 poly(A) polymerase alpha isoform 9
NM_032632.5 NP_116021.2 poly(A) polymerase alpha isoform 1

PAPOLA Protein Structure

PAP_central

PAP_central: Poly(A) polymerase central domain (17 - 364)

NTP_transf_2

NTP_transf_2: Nucleotidyltransferase domain (94 - 173)

PAP_RNA-bind

PAP_RNA-bind: Poly(A) polymerase predicted RNA binding domain (366 - 507)

  • 0
  • 200
  • 400
  • 600
  • 745 a.a.
Protein Preferred Names Protein Names

poly(A) polymerase alpha

polynucleotide adenylyltransferase alpha

Related Diseases

Diseases Alias
46,Xx Sex Reversal 3

SRXX3

Chromosome Xq26 Duplication Syndrome

46,Xx Sex Reversal, Sox3-Related

46xx Sex Reversal 3

46,Xx Male Sex Reversal Sox3-Related
Combat Disorder

Combat Disorders

Combat Neurosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10026 PAPOLA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PAPOLA VGNC VGNC:80891
Canis familiaris PAPOLA VGNC VGNC:50551
Mus musculus PAPOLA MGD MGI:109301
Rattus norvegicus PAPOLA RGD RGD:1308673
Macaca mulatta PAPOLA VGNC VGNC:84415