TMED10 - transmembrane p24 trafficking protein 10 Gene

Homo sapiens

Also known as p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA)

Gene ID: 10972 | Gene type: protein coding

About TMED10

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:75,131,469-75,176,612 (from NCBI)

This gene has 7 transcripts (splice variants), 239 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 111.9), endometrium (RPKM 61.7) and 25 other tissues.

Summary

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

TMED10 Products(1)

mRNA	Protein	Name
NM_006827.6	NP_006818.3	transmembrane emp24 domain-containing protein 10 precursor

TMED10 Protein Structure

EMP24_GP25L

0
100
200
219 a.a.

Protein Preferred Names

Protein Names

transmembrane emp24 domain-containing protein 10

21 kDa transmembrane trafficking protein

Recombinant TMED10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77250	TMP21/p23 Protein, Human (HEK293, Fc)	P49755/NP_006818.3 (I32-R185)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14635	TMED10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMED10	VGNC	VGNC:66247
Macaca mulatta	TMED10	VGNC	VGNC:99273
Bos taurus	TMED10	VGNC	VGNC:35935
Mus musculus	TMED10	MGD	MGI:1915831
Canis familiaris	TMED10	VGNC	VGNC:47437
Rattus norvegicus	TMED10	RGD	RGD:620970
Others	TMED10	NCBI

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