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TMED10 - transmembrane p24 trafficking protein 10 Gene

Also Known as p23; TMP21; p24d1; S31I125; Tmp-21-I; S31III125; P24(DELTA)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10972

About TMED10

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:75,131,469-75,176,612 (from NCBI)

This gene has 7 transcripts (splice variants), 239 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 111.9), endometrium (RPKM 61.7) and 25 other tissues.

Summary

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

TMED10 Products (1)

mRNA	Protein	Name
NM_006827.6	NP_006818.3	transmembrane emp24 domain-containing protein 10 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10359607	GOA
enables protein transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	32272059	GOA
enables syntaxin binding	IPI IPI: Inferred from physical interaction	21545355	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in COPI-coated vesicle budding	IDA IDA: Inferred from direct assay	10052452	GOA
involved in cytosol to ERGIC protein transport	IMP IMP: Inferred from mutant phenotype	32272059	GOA
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	20427317	GOA
involved in positive regulation of interleukin-1 production	IMP IMP: Inferred from mutant phenotype	32272059	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	32272059	GOA
involved in protein localization to ERGIC	IMP IMP: Inferred from mutant phenotype	32272059	GOA
involved in regulation of amyloid-beta formation	IMP IMP: Inferred from mutant phenotype	16641999	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12237308	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12237308	GOA
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	12237308	GOA
part of gamma-secretase complex	IDA IDA: Inferred from direct assay	16641999	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMED10 Protein Structure

EMP24_GP25L

0
100
200
219 a.a.

Protein Preferred Names	Protein Names
transmembrane emp24 domain-containing protein 10	21 kDa transmembrane trafficking protein

TMED10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	TMED10	P49755	nleF	Escherichia coli O157:H7	Q8XAL7	BiFC	23434013
Cross	TMED10	P49755	nleF	Escherichia coli O157:H7	Q8XAL7	IF	23434013
Cross	TMED10	P49755	nleF	Escherichia coli O157:H7	Q8XAL7	Y2H	23434013
Cross	TMED10	P49755	nleF	Escherichia coli O157:H7	Q8XAL7	Y2H Pooling	23434013
Cross	TMED10	P49755	nleF	Escherichia coli O157:H7	Q8XAL7	Anti Tag CoIP	23434013
Intra	TMED10	P49755	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	TMED10	P49755	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	TMED10	P49755	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	TMED10	P49755	PSEN1	Homo sapiens	P49768	Anti Bait CoIP	16641999
Intra	TMED10	P49755	PTPN2	Homo sapiens	P17706-1	Confocal	16595549
Intra	TMED10	P49755	NCSTN	Homo sapiens	Q92542	Anti Bait CoIP	16641999
Intra	TMED10	P49755	PSENEN	Homo sapiens	Q9NZ42	Anti Bait CoIP	16641999
Intra	TMED10	P49755	TMED2	Homo sapiens	Q15363	Anti Bait CoIP	18287528
Intra	TMED10	P49755	TMED2	Homo sapiens	Q15363	Anti Bait CoIP	10359607
Intra	TMED10	P49755	TMED2	Homo sapiens	Q15363	Anti Tag CoIP	20427317
Intra	TMED10	P49755	TMED2	Homo sapiens	Q15363	Anti Bait CoIP	16641999
Intra	TMED10	P49755	TMED2	Homo sapiens	Q15363	Anti Tag CoIP	33961781
Intra	TMED10	P49755	TMED2	Homo sapiens	Q15363	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMED10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77250	TMP21/p23 Protein, Human (HEK293, Fc)	P49755/NP_006818.3 (I32-R185)	≥ 90%, as determined by reducing SDS-PAGE.

TMED10 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87111	TMP21 Antibody (YA6804)	WB, IHC-P, IF-Tissue	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14635	TMED10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19272	Tmed10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25761	Tmed10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	TMED10	VGNC	VGNC:66247
Macaca mulatta	TMED10	VGNC	VGNC:99273
Bos taurus	TMED10	VGNC	VGNC:35935
Mus musculus	TMED10	MGD	MGI:1915831
Canis familiaris	TMED10	VGNC	VGNC:47437
Rattus norvegicus	TMED10	RGD	RGD:620970
Others	TMED10	NCBI