ZHX2 - zinc fingers and homeoboxes 2 Gene

Also Known as RAF; AFR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22882

About ZHX2

Cytogenetic location: 8q24.13 Genomic coordinates (GRCh38): 8:122,781,655-122,974,510 (from NCBI)

This gene has 2 transcripts (splice variants), 237 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 12.8), lymph node (RPKM 11.9) and 25 other tissues.

Summary

The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]

ZHX2 Products (11)

mRNA	Protein	Name
XM_047421585.1	XP_047277541.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_047421584.1	XP_047277540.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_047421589.1	XP_047277545.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_005250836.6	XP_005250893.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_047421588.1	XP_047277544.1	zinc fingers and homeoboxes protein 2 isoform X1
NM_001362797.2	NP_001349726.1	zinc fingers and homeoboxes protein 2
XM_047421590.1	XP_047277546.1	zinc fingers and homeoboxes protein 2 isoform X1
NM_014943.5	NP_055758.1	zinc fingers and homeoboxes protein 2
XM_047421586.1	XP_047277542.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_011516932.4	XP_011515234.1	zinc fingers and homeoboxes protein 2 isoform X1
XM_047421587.1	XP_047277543.1	zinc fingers and homeoboxes protein 2 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Referencias	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	12741956	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12741956	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	12741956	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12741956	GOA

Biological Process GO Annotation	Evidence	Referencias	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12741956	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12741956	GOA

Cellular Component GO Annotation	Evidence	Referencias	Source
is active in nucleus	IDA IDA: Inferred from direct assay	17056598	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12741956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZHX2 Protein Structure

zf-H2C2_5

Homeobox

0
200
400
600
800
837 a.a.

Protein Preferred Names	Protein Names
zinc fingers and homeoboxes protein 2	AFP regulator 1 alpha-fetoprotein regulator 1 regulator of AFP transcription factor ZHX2 zinc finger and homeodomain protein 2

ZHX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Referencias
Intra	ZHX2	Q9Y6X8	TFF2	Homo sapiens	Q03403	Y2H Pooling	32814053
Intra	ZHX2	Q9Y6X8	TFF2	Homo sapiens	Q03403	Validated Y2H	32814053
Intra	ZHX2	Q9Y6X8	TFF2	Homo sapiens	Q03403	Y2H Array	32814053
Intra	ZHX2	Q9Y6X8	AIFM1	Homo sapiens	O95831	Crosslink	30021884
Intra	ZHX2	Q9Y6X8	ZHX2	Homo sapiens	Q9Y6X8	Y2H	12741956
Intra	ZHX2	Q9Y6X8	ZHX2	Homo sapiens	Q9Y6X8	Pull Down	12741956
Intra	ZHX2	Q9Y6X8	Arfgap1	Rattus norvegicus	Q62848	GTPase Assay	22363216

Cross: Cross-species interaction Intra: Intraspecies interaction

ZHX2 Antibodies

Referencia número	Nombre del producto	Aplicación	Reactivity
HY-P82001	ZHX2 Antibody (YA1746)	WB, ICC/IF, FC	Human, Mouse, Rat
HY-P82001A	ZHX2 Antibody (YA1746)(PBS only)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Fetal Hemoglobin Quantitative Trait Locus 1	Hereditary Persistence Of Fetal Hemoglobin Delta-Beta-Thalassemia Delta-Beta Thalassemia Delta Beta-Thalassemia HBFQTL1 Hemoglobin F, Hereditary Persistence Of Hpfh Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related Hemoglobin, Fetal, Quantitative Trait Locus 1 Hereditary Persistence Of Fetal Hemoglobin Thalassemia Hpfh - [Hereditary Persistence Of Fetal Haemoglobin] Fetal Haemoglobin Persistence Of Fetal Haemoglobin Persistent Haemoglobin F
Mitochondrial Complex Iv Deficiency, Nuclear Type 1	Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency Cox Deficiency Cytochrome-C Oxidase Deficiency Disease MC1DN4 Cytochrome-C Oxidase Deficiency MC4DN1 Mitochondrial Complex I Deficiency, Nuclear Type 4 Complex 4 Mitochondrial Respiratory Chain Deficiency Complex Iv Deficiency Mitochondrial Complex 1 Deficiency, Nuclear Type 4 Nuclear Type Mitochondrial Complex I Deficiency 4 Deficiency Of Mitochondrial Respiratory Chain Complex4 MT-C4D Complex Iv Mitochondrial Respiratory Chain Deficiency Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency Mitochondrial Complex Iv Deficiency, Nuclear, Type 1
Nephrotic Syndrome, Type 23	NPHS23 Nephrotic Syndrome Type 23 Nephrotic Syndrome 23

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Referencia número	Nombre del producto	Efecto	Pureza	Rare Diseases
HY-RS16069	ZHX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16070	Zhx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16071	Zhx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZHX2	MGD	MGI:2683087
Canis familiaris	ZHX2	VGNC	VGNC:48632
Bos taurus	ZHX2	VGNC	VGNC:37183
Rattus norvegicus	ZHX2	RGD	RGD:727926
Macaca mulatta	ZHX2	VGNC	VGNC:79148
Felis catus	ZHX2	VGNC	VGNC:67244
Others	ZHX2	NCBI