CDC42EP4 - CDC42 effector protein 4 Gene

Also Known as CEP4; BORG4; KAIA1777

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23580

About CDC42EP4

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:73,283,624-73,312,001 (from NCBI)

This gene has 9 transcripts (splice variants), 238 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 35.1), brain (RPKM 34.5) and 25 other tissues.

Summary

The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin Cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]

CDC42EP4 Products (1)

mRNA Protein Name
NM_012121.5 NP_036253.2 cdc42 effector protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of pseudopodium assembly IDA
IDA: Inferred from direct assay
11035016 GOA
involved in regulation of cell shape IDA
IDA: Inferred from direct assay
11035016 GOA
Cellular Component GO Annotation Evidence References Source
located in adherens junction IDA
IDA: Inferred from direct assay
25468996 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC42EP4 Protein Structure

PBD

PBD: P21-Rho-binding domain (26 - 84)

BORG_CEP

BORG_CEP: Cdc42 effector (112 - 232)

  • 0
  • 100
  • 200
  • 300
  • 356 a.a.
Protein Preferred Names Protein Names

cdc42 effector protein 4

  • CDC42 effector protein (Rho GTPase binding) 4

CDC42EP4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CDC42EP4 Q9H3Q1 FAM9B Homo sapiens Q8IZU0
Y2H Array
31515488
Intra
CDC42EP4 Q9H3Q1 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
CDC42EP4 Q9H3Q1 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02305 CDC42EP4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CDC42EP4 RGD RGD:1311567
Bos taurus CDC42EP4 VGNC VGNC:27075
Felis catus CDC42EP4 VGNC VGNC:98786
Canis familiaris CDC42EP4 VGNC VGNC:39003
Macaca mulatta CDC42EP4 VGNC VGNC:70789
Mus musculus CDC42EP4 MGD MGI:1929760
Others CDC42EP4 NCBI