Htr1a - 5-hydroxytryptamine receptor 1A Gene

Also Known as 5HT1A; RAT5HT1A

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24473

About Htr1a

Primary_assembly 2: 36,694,174-36,695,442 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 66 orthologues, 8 paralogues and is associated with 21 phenotypes.

Summary

Enables several functions, including G protein-coupled serotonin receptor activity; G-protein alpha-subunit binding activity; and serotonin binding activity. Involved in several processes, including NMDA glutamate receptor clustering; adenylate cyclase-inhibiting serotonin receptor signaling pathway; and regulation of secretion. Located in axon hillock. Is active in GABA-ergic synapse. Is integral component of presynaptic membrane. Used to study Parkinson's disease and panic disorder. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A). [provided by Alliance of Genome Resources, Apr 2022]

Htr1a Products (1)

mRNA	Protein	Name
NM_012585.2	NP_036717.2	5-hydroxytryptamine receptor 1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	8271204	RGD
enables G protein-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	12149253	RGD
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	16772521	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18685031	RGD
enables serotonin binding	IDA IDA: Inferred from direct assay	8271204	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	25485703	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in NMDA glutamate receptor clustering	IDA IDA: Inferred from direct assay	18442977	RGD
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8271204	RGD
involved in behavioral response to nicotine	IEP IEP: Inferred from expression pattern	22921986	RGD
involved in negative regulation of gamma-aminobutyric acid secretion	IMP IMP: Inferred from mutant phenotype	30217553	RGD
involved in positive regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	18442977	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	10381597	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	10381597	RGD
involved in regulation of feeding behavior	IDA IDA: Inferred from direct assay	11900812	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	26899441	RGD
involved in response to glycoside	IEP IEP: Inferred from expression pattern	25817367	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	24055683	RGD
involved in serotonin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11927181	RGD

Cellular Component GO Annotation	Evidence	References	Source
is active in GABA-ergic synapse	EXP EXP: Inferred from Experiment	10381597	RGD
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	10381597	RGD
located in axon hillock	IDA IDA: Inferred from direct assay	18622042	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18622042	RGD
is active in presynaptic membrane	EXP EXP: Inferred from Experiment	10381597	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	10381597	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 1A	5-HT-1A 5-HT1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled serotonin 1A receptor serotonin 5-HT1A receptor serotonin receptor 1A

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0735	Phellodendrine chloride		99.68%	Unkown
HY-N0427	Phellodendrine		99.60%	Unkown
HY-RS06458	HTR1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06459	Htr1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06460	Htr1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr1a	NCBI	NCBI:3350