RGS22 - regulator of G protein signaling 22 Gene

Also Known as CT145; PRTD-NY2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26166

About RGS22

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:99,960,936-100,106,049 (from NCBI)

This gene has 17 transcripts (splice variants), 189 orthologues and 23 paralogues. Biased expression in testis (RPKM 35.2), ovary (RPKM 3.9) and 1 other tissue.

Summary

Enables G-protein alpha-subunit binding activity. Predicted to be involved in negative regulation of signal transduction. Located in actin cytoskeleton; cytosol; and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]

RGS22 Products (3)

mRNA Protein Name
NM_001286692.2 NP_001273621.1 regulator of G-protein signaling 22 isoform 2
NM_001286693.2 NP_001273622.1 regulator of G-protein signaling 22 isoform 3
NM_015668.5 NP_056483.3 regulator of G-protein signaling 22 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G-protein alpha-subunit binding IPI
IPI: Inferred from physical interaction
18703424 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18703424 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18703424 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS22 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (676 - 771)

RGS

RGS: Regulator of G protein signaling domain (853 - 977)

RGS

RGS: Regulator of G protein signaling domain (1022 - 1134)

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  • 1264 a.a.
Protein Preferred Names Protein Names

regulator of G-protein signaling 22

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11918 RGS22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22776 Rgs22 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29290 Rgs22 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris RGS22 VGNC VGNC:45532
Rattus norvegicus RGS22 RGD RGD:1565493
Macaca mulatta RGS22 VGNC VGNC:82221
Mus musculus RGS22 MGD MGI:3613651
Felis catus RGS22 VGNC VGNC:81693
Bos taurus RGS22 VGNC VGNC:33921
Others RGS22 NCBI