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Htr2a - 5-hydroxytryptamine receptor 2A Gene

Also Known as 5Ht-2; 5-HT2A

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 29595

About Htr2a

Primary_assembly 15: 49,950,804-50,020,928 forward strand.mRatBN7.2:CM026988.1

This gene has 1 transcript (splice variant), 222 orthologues, 8 paralogues and is associated with 36 phenotypes. Biased expression in Brain (RPKM 49.5), Heart (RPKM 14.5) and 6 other tissues.

Summary

Predicted to enable several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity. Involved in several processes, including blood vessel diameter maintenance; detection of stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including cell body fiber; dendritic shaft; and neuronal cell body. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study congestive heart failure; hyperglycemia; and pancreatitis. Biomarker of bladder neck obstruction and schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A). [provided by Alliance of Genome Resources, Apr 2022]

Htr2a Products (1)

mRNA	Protein	Name
NM_017254.1	NP_058950.1	5-hydroxytryptamine receptor 2A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19590495	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16527989	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in artery smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	14752059	RGD
involved in behavioral response to cocaine	IDA IDA: Inferred from direct assay	23390419	RGD
involved in detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	20531396	RGD
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	20531396	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	16149040	RGD
involved in negative regulation of potassium ion transport	IMP IMP: Inferred from mutant phenotype	16527989	RGD
involved in negative regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	17016851	RGD
involved in phospholipase C-activating serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	17010161	RGD
involved in positive regulation of DNA biosynthetic process	IMP IMP: Inferred from mutant phenotype	18358471	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	24997405	RGD
involved in positive regulation of MAP kinase activity	IMP IMP: Inferred from mutant phenotype	15087293	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15087293	RGD
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	19318092	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	20717650	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	20531396	RGD
involved in positive regulation of execution phase of apoptosis	IDA IDA: Inferred from direct assay	24997405	RGD
involved in positive regulation of heat generation	IMP IMP: Inferred from mutant phenotype	9443541	RGD
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	23362947	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16504407	RGD
involved in positive regulation of platelet aggregation	IMP IMP: Inferred from mutant phenotype	18358471	RGD
involved in positive regulation of vasoconstriction	IMP IMP: Inferred from mutant phenotype	16527989	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	12196574	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	12196574	RGD
involved in regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	15999145	RGD
involved in response to cocaine	IEP IEP: Inferred from expression pattern	25213649	RGD
involved in response to xenobiotic stimulus	IMP IMP: Inferred from mutant phenotype	17077317	RGD
involved in sensitization	IEP IEP: Inferred from expression pattern	25933953	RGD
involved in sensitization	IMP IMP: Inferred from mutant phenotype	20814782	RGD
involved in sensory perception of temperature stimulus	IMP IMP: Inferred from mutant phenotype	20039957	RGD
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	17067560	RGD
involved in urinary bladder smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	23274492	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell body fiber	IDA IDA: Inferred from direct assay	23390419	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10524335	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	18622042	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	12196574	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12196574	RGD
located in neurofilament	IDA IDA: Inferred from direct assay	19362128	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	23390419	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	19362128	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	12535944	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	12535944	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Htr2a Protein Structure

7tmA_5-HT2A

0
100
200
300
400
471 a.a.

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 2A	5-HT-2 5-HT-2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled serotonin 5HT-2 receptor serotonin receptor 2A

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-30234A	Clemizole hydrochloride	Inhibitor	99.99%	Yes
HY-30234	Clemizole	Inhibitor	98.42%	Yes

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-30234S	Clemizole-d4	Inhibitor	99.82%	Unkown
HY-168443	HTR2A antagonist 1		/	Unkown
HY-RS06465	HTR2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06466	Htr2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS06467	Htr2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-30234B	Clemizole sulfate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr2a	NCBI	NCBI:3356