HNRNPH1 - heterogeneous nuclear ribonucleoprotein H1 Gene
Also Known as HNRPH; HNRPH1; NEDCDS; hnRNPH
Species: Homo sapiens
About HNRNPH1
This gene has 50 transcripts (splice variants), 1 gene allele, 143 orthologues, 8 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 153.8), lymph node (RPKM 101.7) and 25 other tissues.
Summary
This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and Other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]
HNRNPH1 Products (52)
| mRNA | Protein | Name |
|---|---|---|
| NM_001257293.2 | NP_001244222.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| NM_001363572.2 | NP_001350501.1 | heterogeneous nuclear ribonucleoprotein H isoform b |
| NM_001364225.2 | NP_001351154.1 | heterogeneous nuclear ribonucleoprotein H isoform c |
| NM_001364226.2 | NP_001351155.1 | heterogeneous nuclear ribonucleoprotein H isoform c |
| NM_001364227.2 | NP_001351156.1 | heterogeneous nuclear ribonucleoprotein H isoform c |
| NM_001364228.2 | NP_001351157.1 | heterogeneous nuclear ribonucleoprotein H isoform c |
| NM_001364229.2 | NP_001351158.1 | heterogeneous nuclear ribonucleoprotein H isoform c |
| NM_001364230.2 | NP_001351159.1 | heterogeneous nuclear ribonucleoprotein H isoform d |
| NM_001364231.2 | NP_001351160.1 | heterogeneous nuclear ribonucleoprotein H isoform l |
| NM_001364232.2 | NP_001351161.1 | heterogeneous nuclear ribonucleoprotein H isoform d |
| NM_001364233.2 | NP_001351162.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| NM_001364234.2 | NP_001351163.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| NM_001364235.2 | NP_001351164.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| NM_001364236.2 | NP_001351165.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| NM_001364237.2 | NP_001351166.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| NM_001364238.2 | NP_001351167.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| NM_001364239.2 | NP_001351168.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| NM_001364240.2 | NP_001351169.1 | heterogeneous nuclear ribonucleoprotein H isoform e |
| NM_001364241.2 | NP_001351170.1 | heterogeneous nuclear ribonucleoprotein H isoform f |
| NM_001364242.2 | NP_001351171.1 | heterogeneous nuclear ribonucleoprotein H isoform f |
| NM_001364243.2 | NP_001351172.1 | heterogeneous nuclear ribonucleoprotein H isoform f |
| NM_001364244.2 | NP_001351173.1 | heterogeneous nuclear ribonucleoprotein H isoform g |
| NM_001364245.2 | NP_001351174.1 | heterogeneous nuclear ribonucleoprotein H isoform b |
| NM_001364246.2 | NP_001351175.1 | heterogeneous nuclear ribonucleoprotein H isoform t |
| NM_001364247.2 | NP_001351176.1 | heterogeneous nuclear ribonucleoprotein H isoform t |
| NM_001364248.2 | NP_001351177.1 | heterogeneous nuclear ribonucleoprotein H isoform h |
| NM_001364250.2 | NP_001351179.1 | heterogeneous nuclear ribonucleoprotein H isoform i |
| NM_001364251.2 | NP_001351180.1 | heterogeneous nuclear ribonucleoprotein H isoform j |
| NM_001364252.2 | NP_001351181.1 | heterogeneous nuclear ribonucleoprotein H isoform j |
| NM_001364253.2 | NP_001351182.1 | heterogeneous nuclear ribonucleoprotein H isoform j |
| NM_001364254.2 | NP_001351183.1 | heterogeneous nuclear ribonucleoprotein H isoform k |
| NM_001364255.2 | NP_001351184.1 | heterogeneous nuclear ribonucleoprotein H isoform k |
| NM_001395176.1 | NP_001382105.1 | heterogeneous nuclear ribonucleoprotein H isoform l |
| NM_001395177.1 | NP_001382106.1 | heterogeneous nuclear ribonucleoprotein H isoform m |
| NM_001395178.1 | NP_001382107.1 | heterogeneous nuclear ribonucleoprotein H isoform n |
| NM_001395179.1 | NP_001382108.1 | heterogeneous nuclear ribonucleoprotein H isoform o |
| NM_001395180.1 | NP_001382109.1 | heterogeneous nuclear ribonucleoprotein H isoform o |
| NM_001395181.1 | NP_001382110.1 | heterogeneous nuclear ribonucleoprotein H isoform p |
| NM_001395182.1 | NP_001382111.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| NM_001395183.1 | NP_001382112.1 | heterogeneous nuclear ribonucleoprotein H isoform q |
| NM_001395184.1 | NP_001382113.1 | heterogeneous nuclear ribonucleoprotein H isoform r |
| NM_001395186.1 | NP_001382115.1 | heterogeneous nuclear ribonucleoprotein H isoform f |
| NM_001395187.1 | NP_001382116.1 | heterogeneous nuclear ribonucleoprotein H isoform g |
| NM_001395188.1 | NP_001382117.1 | heterogeneous nuclear ribonucleoprotein H isoform s |
| NM_001395189.1 | NP_001382118.1 | heterogeneous nuclear ribonucleoprotein H isoform b |
| NM_001395190.1 | NP_001382119.1 | heterogeneous nuclear ribonucleoprotein H isoform u |
| NM_001395191.1 | NP_001382120.1 | heterogeneous nuclear ribonucleoprotein H isoform v |
| NM_001395192.1 | NP_001382121.1 | heterogeneous nuclear ribonucleoprotein H isoform w |
| NM_001395193.1 | NP_001382122.1 | heterogeneous nuclear ribonucleoprotein H isoform x |
| NM_001395194.1 | NP_001382123.1 | heterogeneous nuclear ribonucleoprotein H isoform k |
| NM_001395195.1 | NP_001382124.1 | heterogeneous nuclear ribonucleoprotein H isoform y |
| NM_005520.3 | NP_005511.1 | heterogeneous nuclear ribonucleoprotein H isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables RNA binding |
IDA
IDA: Inferred from direct assay
|
16946708 | GOA |
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
9111328 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in regulation of RNA splicing |
IDA
IDA: Inferred from direct assay
|
16946708 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of catalytic step 2 spliceosome |
IDA
IDA: Inferred from direct assay
|
11991638 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
24910439 | GOA |
HNRNPH1 Protein Structure
(14 - 84)
(113 - 182)
zf-RNPHF: RNPHF zinc finger (255 - 290)
(291 - 358)
- 0
- 100
- 200
- 300
- 400
- 449 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
heterogeneous nuclear ribonucleoprotein H |
|
HNRNPH1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
HNRNPH1 | P31943 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | UBE2I | Homo sapiens | Q7KZS0 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | NFKBID | Homo sapiens | Q8NI38 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | POLR1C | Homo sapiens | O15160 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | ARHGEF16 | Homo sapiens | Q5VV41 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | PATZ1 | Homo sapiens | Q9HBE1-4 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | PATZ1 | Homo sapiens | Q9HBE1-4 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | PATZ1 | Homo sapiens | Q9HBE1-4 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | LMO3 | Homo sapiens | Q8TAP4-4 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | KRTAP13-2 | Homo sapiens | Q52LG2 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | RBFOX2 | Homo sapiens | O43251-10 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | RBFOX2 | Homo sapiens | O43251-10 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | SAXO4 | Homo sapiens | Q7Z5V6-2 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | PEX5 | Homo sapiens | P50542-3 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | PEX5 | Homo sapiens | P50542-3 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | PEX5 | Homo sapiens | P50542-3 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | OXER1 | Homo sapiens | Q8TDS5 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | RNF4 | Homo sapiens | P78317 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | MSI2 | Homo sapiens | Q96DH6 | 35271311 | |
|
Intra
|
HNRNPH1 | P31943 | MSI2 | Homo sapiens | Q96DH6 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | MSI2 | Homo sapiens | Q96DH6 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | MSI2 | Homo sapiens | Q96DH6 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | MRPL53 | Homo sapiens | Q96EL3 | 35271311 | |
|
Intra
|
HNRNPH1 | P31943 | MRPL53 | Homo sapiens | Q96EL3 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | RBM38 | Homo sapiens | Q9H0Z9 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | RBM38 | Homo sapiens | Q9H0Z9 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | RBM38 | Homo sapiens | Q9H0Z9 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | MYPOP | Homo sapiens | Q86VE0 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | NUDT16L1 | Homo sapiens | Q9BRJ7 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | NUDT16L1 | Homo sapiens | Q9BRJ7 | 35271311 | |
|
Intra
|
HNRNPH1 | P31943 | HNRNPF | Homo sapiens | P52597 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | HNRNPM | Homo sapiens | P52272 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | HNRNPM | Homo sapiens | P52272 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | HNRNPF | Homo sapiens | P52597 | 35271311 | |
|
Intra
|
HNRNPH1 | P31943 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
HNRNPH1 | P31943 | TARDBP | Homo sapiens | Q13148 | 29725819 | |
|
Intra
|
HNRNPH1 | P31943 | HNRNPM | Homo sapiens | P52272 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | HNRNPM | Homo sapiens | P52272 | 35271311 | |
|
Intra
|
HNRNPH1 | P31943 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
HNRNPH1 | P31943 | HNRNPA1 | Homo sapiens | P09651 | 35271311 | |
|
Intra
|
HNRNPH1 | P31943 | TARDBP | Homo sapiens | Q13148 | 32814053 | |
|
Intra
|
HNRNPH1 | P31943 | GPS2 | Homo sapiens | Q13227 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | MAGED1 | Homo sapiens | Q9Y5V3 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | MAGED1 | Homo sapiens | Q9Y5V3 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | MAGED1 | Homo sapiens | Q9Y5V3 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | SPG21 | Homo sapiens | Q9NZD8 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | RAMAC | Homo sapiens | Q9BTL3 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | ENKD1 | Homo sapiens | Q9H0I2 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | CATSPER1 | Homo sapiens | Q8NEC5 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | CCDC120 | Homo sapiens | Q96HB5 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | DDX17 | Homo sapiens | Q92841 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | DDX17 | Homo sapiens | Q92841 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | DDX17 | Homo sapiens | Q92841 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | TEKT4 | Homo sapiens | Q8WW24 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | TEKT3 | Homo sapiens | Q9BXF9 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | DZIP3 | Homo sapiens | Q86Y13 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | DZIP3 | Homo sapiens | Q86Y13 | 32296183 | |
|
Intra
|
HNRNPH1 | P31943 | DZIP3 | Homo sapiens | Q86Y13 | 32296183 |
Recombinant HNRNPH1 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P72233 | HNRNPH1 Protein, Human (His-SUMO) | P31943 (M2-A449) | ≥ 90%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Neurodevelopmental Disorder With Craniofacial Dysmorphism And Skeletal Defects |
|
|
| Precursor T-Cell Acute Lymphoblastic Leukemia |
|
|
| Bain Type Of X-Linked Syndromic Intellectual Disability |
|
|
| Intellectual Developmental Disorder, X-Linked, Syndromic, Bain Type |
|
|
| Hereditary Lymphedema |
|
|
| Myotonic Disease |
|
|
| Myotonic Dystrophy 2 |
|
|
| Burkitt Lymphoma |
|
|
| Myotonic Dystrophy 1 |
|
|
| Spinocerebellar Ataxia 8 |
|
|
| Fragile X-Associated Tremor/Ataxia Syndrome |
|
|
| Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1 |
|
|
| Congenital Myasthenic Syndrome |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | HNRNPH1 | RGD | RGD:620840 |
| Mus musculus | HNRNPH1 | MGD | MGI:1891925 |
| Canis familiaris | HNRNPH1 | VGNC | VGNC:51723 |
| Felis catus | HNRNPH1 | VGNC | VGNC:67607 |
| Bos taurus | HNRNPH1 | VGNC | VGNC:52245 |
| Macaca mulatta | HNRNPH1 | VGNC | VGNC:84387 |
| Others | HNRNPH1 | NCBI |