CHAC2 - ChaC glutathione specific gamma-glutamylcyclotransferase 2 Gene

Homo sapiens

Also known as GCG1

Gene ID: 494143 | Gene type: protein coding

About CHAC2

Cytogenetic location: 2p16.2 Genomic coordinates (GRCh38): 2:53,767,783-53,775,196 (from NCBI)

This gene has 1 transcript (splice variant), 213 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues.

Summary

The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances Apoptosis. [provided by RefSeq, Sep 2016]

CHAC2 Products(2)

mRNA	Protein	Name
NM_001008708.4	NP_001008708.1	glutathione-specific gamma-glutamylcyclotransferase 2 isoform 1
NM_001346127.1	NP_001333056.1	glutathione-specific gamma-glutamylcyclotransferase 2 isoform 2

CHAC2 Protein Structure

ChaC

0
100
184 a.a.

Protein Preferred Names

Protein Names

glutathione-specific gamma-glutamylcyclotransferase 2

ChaC cation transport regulator homolog 2

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2d	Pcca
PCH2D	Progressive Cerebello-Cerebral Atrophy
Cerebellocerebral Atrophy, Progressive	Pontocerebellar Hypoplasia 2d
Progressive Cerebellocerebral Atrophy	Hypoplasia, Pontocerebellar, Type 2d

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02591	CHAC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CHAC2	VGNC	VGNC:60833
Mus musculus	CHAC2	MGD	MGI:1915294
Rattus norvegicus	CHAC2	RGD	RGD:1309120
Macaca mulatta	CHAC2	VGNC	VGNC:71151
Bos taurus	CHAC2	VGNC	VGNC:27263
Canis familiaris	CHAC2	VGNC	VGNC:39186

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