HMGCLL1 - 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1 Gene

Homo sapiens

Also known as ERCHL; er-cHL; bA418P12.1

Gene ID: 54511 | Gene type: protein coding

About HMGCLL1

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:55,434,373-55,678,919 (from NCBI)

This gene has 9 transcripts (splice variants), 198 orthologues and 1 paralogue. Broad expression in brain (RPKM 2.9), adrenal (RPKM 1.2) and 14 other tissues.

Summary

Enables hydroxymethylglutaryl-CoA lyase activity. Involved in ketone body biosynthetic process. Located in several cellular components, including cytosol; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HMGCLL1 Products(5)

mRNA	Protein	Name
NM_001042406.2	NP_001035865.1	3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform b
NM_001287741.2	NP_001274670.1	3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform c
NM_001287746.2	NP_001274675.1	3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform d
NM_001287753.2	NP_001274682.1	3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform e
NM_019036.3	NP_061909.2	3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic isoform a

HMGCLL1 Protein Structure

HMGL-like

0
100
200
300
370 a.a.

Protein Preferred Names

Protein Names

3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic

3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1

Related Diseases

Diseases

Alias

Alcoholic Ketoacidosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06237	HMGCLL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HMGCLL1	VGNC	VGNC:29878
Rattus norvegicus	HMGCLL1	RGD	RGD:1565090
Canis familiaris	HMGCLL1	VGNC	VGNC:41713
Mus musculus	HMGCLL1	MGD	MGI:2446108
Macaca mulatta	HMGCLL1	VGNC	VGNC:73429
Felis catus	HMGCLL1	VGNC	VGNC:102440

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