HERC6 - HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55008

About HERC6

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,378,852-88,443,097 (from NCBI)

This gene has 7 transcripts (splice variants), 98 orthologues and 24 paralogues. Ubiquitous expression in esophagus (RPKM 12.4), gall bladder (RPKM 7.3) and 25 other tissues.

Summary

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

HERC6 Products (2)

mRNA Protein Name
NM_001165136.2 NP_001158608.1 probable E3 ubiquitin-protein ligase HERC6 isoform 2
NM_017912.4 NP_060382.3 probable E3 ubiquitin-protein ligase HERC6 isoform 1

HERC6 Protein Structure

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (42 - 90)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (93 - 143)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (148 - 196)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (203 - 251)

RCC1

RCC1: Regulator of chromosome condensation (RCC1) repeat (254 - 301)

HECT

HECT: HECT-domain (ubiquitin-transferase) (724 - 1014)

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  • 1022 a.a.
Protein Preferred Names Protein Names

probable E3 ubiquitin-protein ligase HERC6

  • HECT domain and RCC1-like domain-containing protein 6

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06131 HERC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16311 Herc6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28111 Herc6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HERC6 VGNC VGNC:29815
Macaca mulatta HERC6 VGNC VGNC:73238
Felis catus HERC6 VGNC VGNC:62800
Mus musculus HERC6 MGD MGI:1914388
Rattus norvegicus HERC6 RGD RGD:1561739
Canis familiaris HERC6 VGNC VGNC:41662
Others HERC6 NCBI