HERC6 - HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 Gene

Homo sapiens

Gene ID: 55008 | Gene type: protein coding

About HERC6

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,378,852-88,443,097 (from NCBI)

This gene has 7 transcripts (splice variants), 98 orthologues and 24 paralogues. Ubiquitous expression in esophagus (RPKM 12.4), gall bladder (RPKM 7.3) and 25 other tissues.

Summary

HERC6 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]

HERC6 Products(2)

mRNA	Protein	Name
NM_001165136.2	NP_001158608.1	probable E3 ubiquitin-protein ligase HERC6 isoform 2
NM_017912.4	NP_060382.3	probable E3 ubiquitin-protein ligase HERC6 isoform 1

HERC6 Protein Structure

RCC1

HECT

0
200
400
600
800
1022 a.a.

Protein Preferred Names

Protein Names

probable E3 ubiquitin-protein ligase HERC6

HECT domain and RCC1-like domain-containing protein 6

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06131	HERC6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HERC6	VGNC	VGNC:29815
Macaca mulatta	HERC6	VGNC	VGNC:73238
Felis catus	HERC6	VGNC	VGNC:62800
Mus musculus	HERC6	MGD	MGI:1914388
Rattus norvegicus	HERC6	RGD	RGD:1561739
Canis familiaris	HERC6	VGNC	VGNC:41662

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