SLURP1 - secreted LY6/PLAUR domain containing 1 Gene

Also Known as ARS; MDM; ANUP; ArsB; LY6LS; LY6-MT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57152

About SLURP1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,740,949-142,742,406 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues, 3 paralogues and is associated with 4 phenotypes. Restricted expression toward esophagus (RPKM 167.7).

Summary

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]

SLURP1 Products (1)

mRNA Protein Name
NM_020427.3 NP_065160.1 secreted Ly-6/uPAR-related protein 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine receptor activator activity IDA
IDA: Inferred from direct assay
14506129 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25168896 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
25168896 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
25168896 GOA
involved in urokinase plasminogen activator signaling pathway IDA
IDA: Inferred from direct assay
25168896 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
25919322 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLURP1 Protein Structure

UPAR_LY6

UPAR_LY6: u-PAR/Ly-6 domain (25 - 100)

  • 0
  • 103 a.a.
Protein Preferred Names Protein Names

secreted Ly-6/uPAR-related protein 1

  • ARS(component B)-81/S

SLURP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLURP1 P55000 PLAU Homo sapiens P00749
Anti Tag CoIP
33961781
Intra
SLURP1 P55000 PLAU Homo sapiens P00749
ELISA
25168896
Intra
SLURP1 P55000 CHRNA7 Homo sapiens P36544
Affinity Chrom
26905431
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mal De Meleda

  • Meleda Disease

  • Keratosis Palmoplantaris Transgrediens Of Siemens

  • MDM

  • Transgrediens Palmoplantar Keratoderma Of Siemens

  • Acroerythrokeratoderma

  • Keratosis Palmoplantaris Transgradiens Of Siemens
Palmoplantar Keratoderma, Norrbotten Recessive Type

  • PPKNR

  • Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type

  • Hereditary Palmoplantar Hyperkeratosis, Gamborg-Nielsen Type

  • Ppk, Gamborg-Nielsen Type

  • Keratoderma, Palmoplantar, Norrbotten Recessive Type
Palmoplantar Keratosis

  • Palmoplantar Keratoderma

  • Keratosis Palmaris Et Plantaris

  • Palmo-Plantar Keratodermas

  • Keratoderma, Palmoplantar

  • Keratoderma Palmoplantar

  • Keratoderma, Palmoplantar, Diffuse

  • Hyperkeratosis Of Palms And Soles

  • Palmoplantar Hyperkeratosis
Necrotizing Ulcerative Gingivitis

  • Acute Necrotizing Ulcerative Gingivitis

  • Anug

  • Vincent Angina

  • Vincent'S Disease

  • Acute Necrotising Ulcerative Gingivitis

  • Acute Necrotising Ulcerative Gingivostomatitis

  • Acute Necrotizing Ulcerative Gingivostomatitis

  • Acute Ulceromembranous Gingivitis

  • Angina - Vincents

  • Early Acute Necrotising Gingivitis

  • Trench Mouth

  • Vincent'S Angina

  • Vincent'S Angina - Pharyngitis

  • Vincent'S Infection, Any Site

  • Acute Membranous Gingivitis

  • Fusospirillary Gingivitis

  • Fusospirillosis

  • Phagedenic Gingivitis

  • Vincent'S Gingivitis

  • Vincent'S Infection

  • Vincent'S Stomatitis

  • Gingivitis, Necrotizing Ulcerative
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

  • Focal Nonepidermolytic Palmoplantar Keratoderma

  • Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma

  • FNEPPK1

  • Ppkfne

  • Keratoderma, Focal Nonepidermolytic Palmoplantar

  • Palmoplantar Keratoderma, Nonepidermolytic, Focal

  • Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas

  • Fneppk

  • Focal Nonepidermolytic Palmoplantar Keratoderma 1

  • Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1

  • Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1
Erythrokeratodermia Variabilis Et Progressiva 1

  • Erythrokeratodermia Variabilis

  • Erythrokeratodermia Variabilis Et Progressiva

  • Greither Disease

  • Ekv

  • Ekvp

  • PSEK

  • Erythrokeratodermia Variabilis With Erythema Gyratum Repens

  • Keratosis Palmoplantaris Transgrediens Et Progrediens

  • Transgrediens Et Progrediens Palmoplantar Keratoderma

  • EKVP1

  • Erythrokeratodermia, Progressive Symmetric

  • Erythrokeratodermia Figurata, Congenital Familial, In Plaques

  • Keratoderma Palmoplantaris Transgrediens

  • Keratosis Extremitatum Hereditaria Progrediens

  • Erythrokeratodermia Variabilis, Mendes Da Costa Type

  • Progressive Symmetric Erythrokeratodermia

  • Erythrokeratodermia Figurata Variabilis

  • Greither'S Disease

  • Ekv-P

  • Erythrokeratodermia Variabilis Of Mendes Da Costa

  • Progressive Symmetrical Erythrokeratoderma Of Gottron

  • Progressive Diffuse Ppk

  • Progressive Diffuse Palmoplantar Keratoderma

  • Transgrediens Et Progrediens Ppk

  • Darier-Gottron Disease

  • Erythrokeratodermia Progressiva Symmetrica

  • Progressive Symmetric Erythrokeratodermia, Gottron Type

  • Congenital Familial Erythrokeratodermia Figurata In Plaques

  • Erythrokeratodermia Progressive Symmetric

  • Erythrokeratodermia Variabilis Mendes Da Costa Type
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

  • Olmsted Syndrome

  • Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques

  • Palmoplantar And Periorificial Keratoderma

  • Olms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13385 SLURP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLURP1 VGNC VGNC:81699
Rattus norvegicus SLURP1 RGD RGD:1308768
Bos taurus SLURP1 VGNC VGNC:34972
Canis familiaris SLURP1 VGNC VGNC:46516
Macaca mulatta SLURP1 VGNC VGNC:82242
Mus musculus SLURP1 MGD MGI:1930923