SLURP1 - secreted LY6/PLAUR domain containing 1 Gene

Homo sapiens

Also known as ARS; MDM; ANUP; ArsB; LY6LS; LY6-MT

Gene ID: 57152 | Gene type: protein coding

About SLURP1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:142,740,949-142,742,406 (from NCBI)

This gene has 1 transcript (splice variant), 80 orthologues, 3 paralogues and is associated with 4 phenotypes. Restricted expression toward esophagus (RPKM 167.7).

Summary

The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]

SLURP1 Products(1)

mRNA	Protein	Name
NM_020427.3	NP_065160.1	secreted Ly-6/uPAR-related protein 1 precursor

SLURP1 Protein Structure

UPAR_LY6

0
103 a.a.

Protein Preferred Names

Protein Names

secreted Ly-6/uPAR-related protein 1

ARS(component B)-81/S

Related Diseases

Diseases

Alias

Mal De Meleda

Meleda Disease	Keratosis Palmoplantaris Transgrediens Of Siemens
MDM	Transgrediens Palmoplantar Keratoderma Of Siemens
Acroerythrokeratoderma	Keratosis Palmoplantaris Transgradiens Of Siemens

Palmoplantar Keratoderma, Norrbotten Recessive Type

PPKNR	Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type
Hereditary Palmoplantar Hyperkeratosis, Gamborg-Nielsen Type	Ppk, Gamborg-Nielsen Type
Keratoderma, Palmoplantar, Norrbotten Recessive Type

Palmoplantar Keratosis

Palmoplantar Keratoderma	Keratosis Palmaris Et Plantaris
Palmo-Plantar Keratodermas	Keratoderma, Palmoplantar
Keratoderma Palmoplantar	Keratoderma, Palmoplantar, Diffuse
Hyperkeratosis Of Palms And Soles	Palmoplantar Hyperkeratosis

Necrotizing Ulcerative Gingivitis

Acute Necrotizing Ulcerative Gingivitis	Anug
Vincent Angina	Vincent'S Disease
Acute Necrotising Ulcerative Gingivitis	Acute Necrotising Ulcerative Gingivostomatitis
Acute Necrotizing Ulcerative Gingivostomatitis	Acute Ulceromembranous Gingivitis
Angina - Vincents	Early Acute Necrotising Gingivitis
Trench Mouth	Vincent'S Angina
Vincent'S Angina - Pharyngitis	Vincent'S Infection, Any Site
Acute Membranous Gingivitis	Fusospirillary Gingivitis
Fusospirillosis	Phagedenic Gingivitis
Vincent'S Gingivitis	Vincent'S Infection
Vincent'S Stomatitis	Gingivitis, Necrotizing Ulcerative

Skin Disease

Skin Diseases	Genodermatosis
Abnormality Of The Skin	Skin Diseases, Genetic
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Palmoplantar Keratoderma, Nonepidermolytic, Focal 1

Focal Nonepidermolytic Palmoplantar Keratoderma	Isolated Focal Non-Epidermolytic Palmoplantar Keratoderma
FNEPPK1	Ppkfne
Keratoderma, Focal Nonepidermolytic Palmoplantar	Palmoplantar Keratoderma, Nonepidermolytic, Focal
Hyperkeratosis Of The Palms And Soles And Esophageal Papillomas	Fneppk
Focal Nonepidermolytic Palmoplantar Keratoderma 1	Keratoderma, Palmoplantar, Non-Epidermolytic, Focal 1
Keratoderma, Palmoplantar, Nonepidermolytic, Focal, Type 1

Erythrokeratodermia Variabilis Et Progressiva 1

Erythrokeratodermia Variabilis	Erythrokeratodermia Variabilis Et Progressiva
Greither Disease	Ekv
Ekvp	PSEK
Erythrokeratodermia Variabilis With Erythema Gyratum Repens	Keratosis Palmoplantaris Transgrediens Et Progrediens
Transgrediens Et Progrediens Palmoplantar Keratoderma	EKVP1
Erythrokeratodermia, Progressive Symmetric	Erythrokeratodermia Figurata, Congenital Familial, In Plaques
Keratoderma Palmoplantaris Transgrediens	Keratosis Extremitatum Hereditaria Progrediens
Erythrokeratodermia Variabilis, Mendes Da Costa Type	Progressive Symmetric Erythrokeratodermia
Erythrokeratodermia Figurata Variabilis	Greither'S Disease
Ekv-P	Erythrokeratodermia Variabilis Of Mendes Da Costa
Progressive Symmetrical Erythrokeratoderma Of Gottron	Progressive Diffuse Ppk
Progressive Diffuse Palmoplantar Keratoderma	Transgrediens Et Progrediens Ppk
Darier-Gottron Disease	Erythrokeratodermia Progressiva Symmetrica
Progressive Symmetric Erythrokeratodermia, Gottron Type	Congenital Familial Erythrokeratodermia Figurata In Plaques
Erythrokeratodermia Progressive Symmetric	Erythrokeratodermia Variabilis Mendes Da Costa Type

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13385	SLURP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SLURP1	VGNC	VGNC:81699
Rattus norvegicus	SLURP1	RGD	RGD:1308768
Bos taurus	SLURP1	VGNC	VGNC:34972
Canis familiaris	SLURP1	VGNC	VGNC:46516
Macaca mulatta	SLURP1	VGNC	VGNC:82242
Mus musculus	SLURP1	MGD	MGI:1930923

Name
Email *

	Sorry, but the email address you supplied was invalid.